215997-72-1Relevant academic research and scientific papers
Convenient synthesis of 2-substituted indoles from 2-ethynylanilines with tetrabutylammonium fluoride
Yasuhara, Akito,Kanamori, Yuichi,Kaneko, Masashi,Numata, Atsushi,Kondo, Yoshinori,Sakamoto, Takao
, p. 529 - 534 (2007/10/03)
The cyclization reaction of various 2-ethynylanilines, which were easily synthesized from 2-haloanilines by the palladium-catalyzed reaction with terminal alkynes, with tetrabutylammonium fluoride (TBAF) to yield 2-substituted indoles proceeded at refluxing or room temperature in THF in excellent yields without affecting the bromo, chloro, cyano, ethoxycarbonyl, and ethynyl groups.
