21602-91-5

Upstream product

• 32023-47-5 3-(5-nitrofuran-2-yl)-1-phenylprop-2-yn-1-one 
• 4332-88-1 3-(5-nitrofuran-2-yl)-1-phenylprop-2-en-1-one 
• 38874-88-3 2,3-dibromo-3-(5-nitrofuran-2-yl)-1-phenylpropan-1-one 
• 141244-76-0 5-phenyl-1-(o-chlorophenyloxyacetyl)-5-hydroxy-3-(5-nitro-2-furyl)pyrazoline 

Relevant academic research and scientific papers

Reaction of anilinoacet hydrazides with α,β-acetylenic ketones and structural characterization of new compounds

Reactions of 1-aryl-3-(5-nitro-2-thienyl/furyl)-2-propyne-1-one 3 with anilinoacet hydrazides 4, give the 1-anilinoacetyl-3-(5-nitro-2-thienyl/furyl)-5-aryl-5-hydroxypyrazolines 5-6 rather than the expected pyrazoles 7-8. Various attempts have been made for the conversion of 5-6 to 7-8. The studies also reveal that the carbonyl group in 4 is responsible for the formation of hydroxypyrazolines. The structures of newly synthesized compounds have been proposed on the basis of elemental analysis and spectral data, and in some cases through the synthesis of authentic samples by alternative routes.

Reactions of aryloxyacetylhydrazines with α,β-acetylinic ketones

Reactions of aryloxyacetyl hydrazines with 1-aryl-3-(5-nitro-2-furyl)-2-propyn-1-ones (3) yield 5-aryl-1-aryloxyacetyl-5-hydroxy-3-(5-nitro-2-furyl)-pyrazolines (4) rather than the expected pyrazoles (5).These hydroxypyrazolines have been subjected to acid-catalyzed dehydration.Dehydration using con. sulfuric acid in refluxing ethanol yields 5-aryl-3-(5-nitro-2-furyl)pyrazoles (6) while on stirring with a few drops of con. sulphuric acid in gl. acetic acid results in the formation of 5-aryl-1-aryloxyacetyl-3-(5-nitro-2-furyl)pyrazoles (5).