21605-68-5Relevant academic research and scientific papers
Synthesis of 4-acetyl (or carbethoxy) -5-methyl-1-heterocyclylpyrazoles
Singh, Shiv P.,Kapoor, Jitander K.,Sadana, Anil K.
, p. 49 - 54 (2001)
Reaction of heterocyclylhydrazines (1a-f) with 3-ethoxymethylenepentane-2,4-dione (2) and ethyl 2-ethoxymethylene-3-oxobutyrate (3) yields exclusively 4-acetyl-5-methyl-1-heterocyclylpyrazoles (4a-f) and 4-carbethoxy-5-methyl-1-heterocyclylpyrazoles (5a-f
N → N acyl group migration in N-acylpyrazoles: Isomerization of 1,4-diacyl-5-methyl-1H-pyrazoles to 1,4-diacyl-3-methyl-1H-pyrazoles
Petrov,Pakal’nis,Zerov,Yakimovich
, p. 381 - 392 (2017/05/10)
1,4-Diacyl-5-methyl-1H-pyrazoles on heating in toluene undergo isomerization to 1,4-diacyl-3-methyl-1H-pyrazoles via intermolecular N → N acyl group migration. 1,4,5-Trisubstituted pyrazoles obtained by reaction of 2-ethoxymethylidene derivatives of 1,3-diketones with 1,3-benzothiazol-2-ylhydrazine or phenylhydrazine failed to isomerize to 1,3,4-trisubstituted pyrazoles.
Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. III. Synthesis and antitumor activity of 3-phenylpiperazinyl-1-trans-propenes
Naito, Hiroyuki,Ohsuki, Satoru,Atsumi, Ryo,Minami, Megumi,Mochizuki, Mineko,Hirotani, Kenji,Kumazawa, Eiji,Ejima, Akio
, p. 153 - 163 (2007/10/03)
A series of novel 3-[4-phenyl-1-piperazinyl]-1-[5-methyl-1-(2-pyrimidinyl)- 4-pyrazolyl]-1-trans-propenes and related compounds were synthesized and evaluated by their cytotoxic activity against several tumor cell lines in vitro and in vivo antitumor acti
