2160535-59-9Relevant academic research and scientific papers
Pd/PC-Phos-Catalyzed Enantioselective Intermolecular Denitrogenative Cyclization of Benzotriazoles with Allenes and N-Allenamides
Zhang, Pei-Chao,Han, Jie,Zhang, Junliang
, p. 11444 - 11448 (2019/07/17)
Reported herein is an asymmetric Pd/PC-Phos-catalyzed denitrogenative cyclization of benzotriazoles with allenes and N-allenamides, representing the first example of enantioselective denitrogenative cyclizations of benzotriazoles. A series of optically active 3-methyleneindolines were obtained in good yields with high ee values. The use of inexpensive and readily available starting materials, high regio- and enantioselectivity, a broad substrate scope, mild reaction conditions, no need for base, as well as versatile functionalization of the 3-methyleneindolines make this approach attractive.
Gold-Catalyzed Asymmetric Intramolecular Cyclization of N-Allenamides for the Synthesis of Chiral Tetrahydrocarbolines
Wang, Yidong,Zhang, Peichao,Di, Xiaoyu,Dai, Qiang,Zhang, Zhan-Ming,Zhang, Junliang
supporting information, p. 15905 - 15909 (2017/11/27)
Highly enantioselective gold-catalyzed intramolecular cyclization of N-allenamides was implemented by utilizing a designed chiral sulfinamide phosphine ligand (PC-Phos). This represents the first example of highly enantioselective intramolecular cyclization of N-allenamides. The practicality of this reaction was validated in the total synthesis of (R)-desbromoarborescidine A and formal synthesis of (R)-desbromoarborescidine C and (R)-deplancheine. Moreover, the catalyst system PC-Phos/AuNTf2 proved to be specifically efficient to promote the desymmetrization of N-allenamides in excellent yields with satisfactory ee values.
Based on xanthene skeleton of PC - Phos chiral shan lin ligands and its full configuration of the preparation method and application (by machine translation)
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Paragraph 0120; 0126; 0131; 0132, (2018/03/24)
The invention discloses a xanthene skeleton model PC - Phos monophosphine ligand, the ligands of formula (1) compounds of formula or its enantiomer, racemate or non-enantiomer The invention also discloses the preparation method of the ligand, in order to type 2 Formula 4 As raw materials, the substitution reaction, addition reaction, condensation reaction, the reduction reaction of the preparation to the ligand; intercept a 6 Formula 4 As the raw material, a condensation reaction, and The addition reaction to the ligand. The present invention through the use of two configurations deodoration sulfonamide 4 and different types of metal reagent addition reaction, can be obtained by the ligand states chiral shan lin 1 (S, Rs ), 1 (R, Rs ), 1 (S, Ss ) And 1 (R, Ss ) Of four full-configuration of optically pure. The invention also discloses the ligands catalytic connected enamine in the molecule in the asymmetric cyclization reaction of application, has very high reaction activity and stereo selectivity, has wide application value. (by machine translation)
