216062-06-5

Basic information

• Product Name: (1'R,3S)-1-tert-butyloxycarbonyl-3-(1',2'-diphenylethoxy)pyrrolidine
• Synonyms: (1'R,3S)-1-tert-butyloxycarbonyl-3-(1',2'-diphenylethoxy)pyrrolidine
• CAS NO: 216062-06-5
• Molecular Weight: 367.488
• Mol File: 216062-06-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1'R,3S)-1-tert-butyloxycarbonyl-3-(1',2'-diphenylethoxy)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (1'R,3S)-1-tert-butyloxycarbonyl-3-(1',2'-diphenylethoxy)pyrrolidine(216062-06-5)
• EPA Substance Registry System: (1'R,3S)-1-tert-butyloxycarbonyl-3-(1',2'-diphenylethoxy)pyrrolidine(216062-06-5)

Safety Data

• Hazardous Substances Data: 216062-06-5(Hazardous Substances Data)

Upstream product

• 216062-05-4 (2S,3R,6S)-6-(2-Hydroxy-ethyl)-2,3-diphenyl-morpholine-4-carboxylic acid benzyl ester 
• 213686-90-9 (2S,5R,6S)-4-(benzyloxycarbonyl)-5,6-diphenyl-2(2-propenyl)-1,2,5,6-tetrahydro-4H-1,4-oxazine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 101469-92-5 (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Asymmetric synthesis of 1-Boc-3- and 4-hydroxypyrrolidines

Lewis Acid-mediated coupling reactions of (5R, 6S)-2-acetoxy-4- (benzyloxycarbonyl)-5,6-diphenyl-2,3,5,6-tetrahydro-4H-1,4-oxazine (2a) with allylsilanes (3a-d) proceeded to give the coupling products (4a-b) with moderate to good stereoselectivity. The coupling products (4a-b) were effectively converted into 1-Boc-3- and 4-hydroxypyrrolidines (8a, syn-b, and c).