216076-70-9Relevant academic research and scientific papers
Coupling-isomerization-Stetter and coupling-isomerization-Stetter-Paal- Knorr sequences - A multicomponent approach to furans and pyrroles
Braun, Roland U.,Mueller, Thomas J. J.
, p. 2391 - 2406 (2007/10/03)
2,3,5-Trisubstituted furans 6 and 1,2,3,5-tetrasubstituted pyrroles 8 can be synthesized in good yields in a one-pot three-step three- or four-component process by a coupling-isomerization-Stetter-Paal-Knorr sequence of an electron-poor (hetero)aryl halid
Pyrroles and other heterocycles as inhibitors of P38 kinase
De Laszlo, Stephen E.,Visco, Denise,Agarwal, Lily,Chang, Linda,Chin, Jayne,Croft, Gist,Forsyth, Amy,Fletcher, Daniel,Frantz, Betsy,Hacker, Candice,Hanlon, William,Harper, Coral,Kostura, Matthew,Li, Bing,Luell, Sylvie,MacCoss, Malcolm,Mantlo, Nathan,O'Neill, Edward A.,Orevillo, Chad,Pang, Margaret,Parsons, Janey,Rolando, Anna,Sahly, Yousif,Sidler, Kelley,Widmer, W. Rick,O'Keefe, Stephen J.
, p. 2689 - 2694 (2007/10/03)
Investigation of furans, pyrroles and pyrazolones identified 3-pyridyl- 2,5-diaryl-pyrroles as potent, orally bioavailable inhibitors of p38 kinase. 3-(4-pyridyl-2-(4-fluoro-phenyl)-5-(4-methylsulfinylphenyl)-pyrrole (L- 167307)) reduces secondary paw swe
