216083-41-9Relevant academic research and scientific papers
Heterocyclic synthesis with nitriles: Synthesis of some novel pyrrolo [2,1-b]thiadiazoline, pyrrolo[2,1-b]thiadiazolo[3,2-a]pyrimidine and pyridine derivatives
Metwally, Nadia H.,Abdelrazek, Fathy M.
experimental part, p. 676 - 678 (2011/10/09)
α-(Bromothiocyanatomethyl)benzylidenemalononitrile (1) reacts with the hydrazides 2a-c, cyanoacetohydrazide (2d), cyanoacetamide (3a) and cyanoacetanilides 3b-d to afford pyrrolo[2,1-b]thiadiazolines 5a-c, pyrrolo[2,1-6]thia-diazolo[3,2-a]pyrimidine (8) and the pyridone derivatives 11a-d. Structures and conceivable mechanisms are discussed.
