21613-44-5

Basic information

• Product Name: (2E)-4-phenylbut-3-en-2-one oxime
• CAS NO: 21613-44-5
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2004
• Mol File: 21613-44-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 304.3°C at 760 mmHg
• Flash Point: 183.5°C
• Density: 0.97g/cm³
• Vapor Pressure: 0.000387mmHg at 25°C
• Refractive Index: 1.511
• CAS DataBase Reference: (2E)-4-phenylbut-3-en-2-one oxime(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-4-phenylbut-3-en-2-one oxime(21613-44-5)
• EPA Substance Registry System: (2E)-4-phenylbut-3-en-2-one oxime(21613-44-5)

Safety Data

• Hazardous Substances Data: 21613-44-5(Hazardous Substances Data)

Usage

General Description

(2E)-4-phenylbut-3-en-2-one oxime is a compound with the chemical formula C10H11NO. It is an oxime derivative of 4-phenylbut-3-en-2-one, which is a highly reactive organic compound often used in the synthesis of various chemicals. The oxime form of this compound, also known as 4-phenyl-3-buten-2-one oxime, is commonly used as a reagent in the organic chemistry for the preparation of other organic compounds. It is also used in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical compounds. Additionally, this compound has been studied for its potential biological activities, such as its potential role as an antioxidant and as an antihypertensive agent. Overall, (2E)-4-phenylbut-3-en-2-one oxime is a versatile compound with important applications in organic synthesis and pharmaceutical research.

Upstream product

• 1896-62-4 (E)-benzalacetone 
• 21613-45-6 (Z,E)-4-Phenyl-3-buten-2-on-oxim 

Downstream Products

• 86069-33-2 (E)-4-Phenyl-but-3-en-2-one O-(1-ethyl-pyrrolidin-2-ylmethyl)-oxime 
• 86069-32-1 (E)-4-Phenyl-but-3-en-2-one O-(1-ethyl-piperidin-3-yl)-oxime 
• 176433-57-1 2-chloro-5-phenyl-3-pyridine carboxaldehyde 
• 1619986-37-6 C₁₀H₁₃NO₂ 
• 1416563-22-8 5-methyl-1-[2-(E)-phenylethenyl]tetrazole 
• 1357560-48-5 2,3-bis(3-bromophenyl)-6-methyl-4-phenylpyridine 
• 1357560-47-4 6-methyl-4-phenyl-2,3-bis(4-(trimethylsilyl)phenyl)pyridine 
• 1357560-50-9 2,3-bis(tert-butyldimethylsilyloxymethyl)-6-methyl-4-phenylpyridine 
• 1357560-88-3 ethyl 3,4-diphenyl-6-methylpyridine-2-carboxylate 
• 1350770-11-4 6-methyl-2,3,4-triphenylpyridine 
• 1357560-51-0 3-(4-methoxyphenyl)-6-methyl-4-phenyl-2-(4-(trifluoromethyl)phenyl)pyridine 
• 1357560-89-4 2-(4-methoxyphenyl)-6-methyl-4-phenyl-3-(4-(trifluoromethyl)phenyl)pyridine 
• 1357560-46-3 2,3-bis(4-methoxyphenyl)-6-methyl-4-phenylpyridine 
• 1357560-49-6 6-methyl-4-phenyl-2,3-dipropylpyridine 

Relevant articles and documents

Amine-free approach toward N-toluenesulfonyl amidine construction: A phosphite-mediated beckmann-like coupling of oximes and p-toluenesulfonyl azide

Atom hopping: A chlorophosphite-mediated Beckmann ligation of oximes and p-toluenesulfonyl azide gives access to N-sulfonyl phosphoramidines in good to excellent yields. The reaction proceeds under exceptionally mild conditions and constitutes a bioorthogonal approach toward amidines by avoiding the use of amines and transition-metal catalysts. dmp-ol=3,3-dimethylpropanediol. Copyright

o-Phthalic Anhydride/Zn(OTf)2 co-catalyzed Beckmann rearrangement under mild conditions

o-Phthalic anhydride/Zn(OTf)2 co-catalyzed Beckmann rearrangement was developed, producing the corresponding amide in up to 99% yield with acid-sensitive functionalities tolerated well, and the scale of the reaction could be enlarged to 77 mmol and the excellent yield was maintained. A successive procedure was developed. Moreover, the reaction was carried out at rt under nearly neutral conditions, and the workup was concise. These features illustrated the potential of the protocol in amide synthesis.

Cu(ii)-Catalyzed asymmetric boron conjugate addition to α,β-unsaturated imines in water

Enantioselective conjugate addition of bis(pinacolato)diboron to α,β-unsaturated imines proceeds smoothly in water in the presence of a chiral copper(ii) complex consisting of Cu(OAc)2 and chiral 2,2′-bipyridine. The corresponding β-boryl imines, which were oxidized to β-hydroxy imines, further leading to γ-amino alcohols, were obtained in high yields and high enantioselectivities.