216169-57-2Relevant academic research and scientific papers
Practical enantioselective synthesis of β-substituted-β-amino esters
Awasthi, Alok K.,Boys, Mark L.,Cain-Janicki, Kimberly J.,Colson, Pierre-Jean,Doubleday, Wendel W.,Duran, Joseph E.,Farid, Payman N.
, p. 5387 - 5397 (2007/10/03)
A practical, large-scale synthesis of a β-amino ester 1 was developed. A chiral imine derived from (S)-phenylglycinol and 3-trimethylsilylpropanal was coupled with the Reformatsky reagent 3 with high diastereoselectivity (de > 98%) to give (SS)-4a as the
