216252-71-0

Upstream product

• 850804-13-6 3-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-propionitrile 
• 239807-64-8 3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propylcarbamic acid, 1,1-dimethylethyl ester 

Downstream Products

• 614747-29-4 1-[3-{4-(2-isopropoxyphenyl)-piperazin-1-yl}-propyl]-pyrrole-2,5-dione 

Relevant academic research and scientific papers

METABOLITES OF 2-{3-[4-(2-ISOPROPOXYPHENYL) PIPERAZIN-1-YL]-PROPYL}-3A,4,7,7A-TETRAHYDRO-1H-ISOINDOLE-1,3-(2H)-DIONE

The present invention relates to the metabolites of 2-{3-[4-(2-isopropoxyphenyl) piperazin-1-yl]-propyl}-3a,4,7,7a -tetrahydro-1H-isoindole-1,3(2H)-dione of Formula I. The disclosed compounds can function as 1a-adrenoceptor antagonists and thus can be used for the treatment of benign prostatic hyperplasia (BPH) and related symptoms thereof. Processes for preparing the metabolites, pharmaceutical composition containing these metabolites and the method of treating BPH and related symptoms thereof are also provided.

1-ALKYLPIPERAZINYL-PYRROLIDIN-2, 5-DIONE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONIST

Compounds of formula (I), disclosed herein can function as α1a and/or α1d adrenergic receptor antagonists and can be used for the treatment of benign prostatic hyperplasia and related symptoms thereof. Compounds disclosed herein can

PHTHALIMIDO ARYLPIPERAZINES USEFUL IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA

This invention relates to a series of substituted piperazines of Formula II, as well as enantiomers thereof These compounds are useful in the manufacture of pharmaceutical compositions.

Design, synthesis, and structure-activity relationships of phthalimide- phenylpiperazines: A novel series of potent and selective {1a)-adrenergic receptor antagonists

Beginning from the screening hit and literature α1-adrenergic compounds, a hybridized basic skeleton A was proposed as the pharmacophore for potent and selective α(1a)-AR antagonists. Introduction of a hydroxy group to increase the flexibility

Design, synthesis and biological evaluation of pyridine-phenylpiperazines: A novel series of potent and selective α(1a)-adrenergic receptor antagonist

Beginning from the screening hit and literature α1-adrenergic compounds, a hybridized basic skeleton A was proposed as the pharmacophore for potent and selective α(1a)-AR antagonists. Introduction of a hydroxy group to increase the flexibility