21626-53-9Relevant academic research and scientific papers
Design of antineoplastic agents based on the '2-phenylnaphthalene-type' structural pattern - Synthesis and biological activity studies of 11H-indolo[3.2-c]quinoline derivatives
He, Ling,Chang, He-Xi,Chou, Ting-Chao,Savaraj, Niramol,Cheng
, p. 101 - 107 (2003)
Designed as a new group of planar molecule containing the proposed 2-phenylnaphthalene-type structure, a number of 11H-indolo[3.2-c]quinoline derivatives were synthesized and evaluated biologically. Several compounds were found to possess cytotoxic activity against the growth of human promyelocytic leukemia cells (HL-60), against the small cell lung cancer (SCLC), and showed good response in the National Cancer Institute preclinical antitumor drug discovery 60-cell line panel.
Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents
Zhou, Yuanyuan,Yan, Wei,Cao, Dong,Shao, Mingfeng,Li, Dan,Wang, Fang,Yang, Zhuang,Chen, Yong,He, Linhong,Wang, Taijin,Shen, Mingsheng,Chen, Lijuan
, p. 1114 - 1125 (2017)
A series of novel 4-anilinoquinoline derivatives were synthesized and evaluated for their antiproliferative activities. Among them, 14h exhibited the most potent cytotoxic activity with IC50 values ranging from 1.5 to 3.9 nM against all tested cancer cell lines, and showed promising efficacy in multidrug resistant cancer cells. Flow cytometry assay, immune-fluorescence staining, microtubule dynamics assays and competition assays with EBI identified that 14h was a novel tubulin depolymerization agent by binding to the colchicine site. Importantly, in vivo efficacy evaluation of HCT116 xenograft model, 14h showed efficient antitumor activity without significant loss in body weight. All the results indicated that 14h could be a promising candidate for the treatment of cancer.
AMINE COMPOUNDS HAVING ANTI-INFLAMMATORY, ANTIFUNGAL, ANTIPARASITIC AND ANTICANCER ACTIVITY
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Page/Page column 119, (2014/08/19)
Amine compounds having activity against inflammation, fungi, unicellular parasitic microorganisms, and cancer are described. The compounds contain a monocyclic, bicyclic, or tricyclic aromatic ring having one, two, or three ring nitrogen atoms.
Auto-tandem catalysis: Synthesis of substituted 11H-indolo [3,2-c]quinolines via palladium-catalyzed intermolecular C-N and intramolecular C-C bond formation
Meyers, Caroline,Rombouts, Geert,Loones, Kristof T. J.,Coelho, Alberto,Maes, Bert U. W.
supporting information; experimental part, p. 465 - 470 (2009/04/10)
D-Ring substituted 11H-indolo[3,2-c]quinolines (4) have been prepared via auto-tandem consecutive intermolecular Buchwald-Hartwig reaction and intramolecular palladium-catalyzed arylation on 4-chloroquinoline (1) with N-unsubstituted 2-chloroanilines (2).
