21627-33-8Relevant academic research and scientific papers
Novel ruthenium(II) complexes with substituted 1,10-phenanthroline or 4,5-diazafluorene linked to a fullerene as highly active second order NLO chromophores
Valore, Adriana,Balordi, Marcella,Colombo, Alessia,Dragonetti, Claudia,Righetto, Stefania,Roberto, Dominique,Ugo, Renato,Benincori, Tiziana,Rampinini, Giovanni,Sannicolo, Francesco,Demartin, Francesco
, p. 10314 - 10318 (2010)
Various Ru(II) complexes with substituted 1,10-phenanthroline or 4,5-diazafluorene are characterized by a good to very large second order NLO response, as determined by EFISH. Among these complexes, [Ru(9-fulleriden-4,5- diazafluorene)(PPh3)2Cl2] is particularly appealing due to its huge second-order NLO response and its transparency to the second harmonic generation. The structure of cis-Cl,trans-PPh 3-[Ru(5-NO2-1,10-phen)(PPh3)2Cl 2)] was determined by single-crystal X-ray diffraction. The Royal Society of Chemistry 2010.
Ru(II)/N-N/PPh3 complexes as potential anticancer agents against MDA-MB-231 cancer cells (N-N?=?diimine or diamine)
Ribeiro, Gabriel H.,Colina-Vegas, Legna,Clavijo, Juan C.T.,Ellena, Javier,Cominetti, Marcia R.,Batista, Alzir A.
, p. 70 - 83 (2019/01/26)
The rational design of anticancer agents that acts in specific biological targets is one of the most effective strategies for developing chemotherapeutic agents. Aiming at obtaining new ruthenium (II) compounds with good cytotoxicity against tumor cells, a series of new complexes of general formula [RuCl(PPh3)(Hdpa)(N–N)]Cl [PPh3 = triphenylphosphine, N-N = 2,2′-dipyridylamine (Hdpa) (1), 1,2-diaminoethane (en) (2), 2,2′-bipyridine (bipy) (3), 5,5′-dimethyl-2,2′-bipyridine (dmbipy) (4), 1,10-phenanthroline (phen) (5) and 4,7-diphenyl-1,10-phenanthroline (dphphen) (6)] were synthesized. The complexes were characterized by elemental analysis and spectroscopic techniques (IR, UV/Visible, and 1D and 2D NMR) and three of their X-ray structures were determined: [RuCl(PPh3)(Hdpa)2]Cl, [RuCl(PPh3)(Hdpa)(en)]Cl and [RuCl(PPh3)(Hdpa)(dmbipy)]Cl. All the complexes are more cytotoxic against the cancer cell line than against the non-tumor cell line, highlighting complexes 1 and 5, which have an index selectivity of 18 and 15, respectively. The binding constants of compounds 1–6 with human serum albumin (HSA) were determined by tryptophan fluorescence quenching, indicating moderate to strong interactions. The binding mode of the complexes to calf thymus (CT) DNA was explored by several techniques, which reveal that only the dphphen compound 6 causes distortions in the secondary and tertiary structures of DNA. The studies demonstrated that the nature of the N–N co-ligand and the presence of the PPh3 and Hdpa ligands are features that can influence the binding affinity of the complexes by the biomolecules and in the cytotoxic activity of the complexes. Overall, the complexes with diimine co-ligand are much more cytotoxic than compound 2 with the aliphatic diamine.
Antiparasitic activities of novel ruthenium/lapachol complexes
Barbosa, Marília I.F.,Corrêa, Rodrigo S.,De Oliveira, Katia Mara,Rodrigues, Claudia,Ellena, Javier,Nascimento, Otaciro R.,Rocha, Vinícius P.C.,Nonato, Fabiana R.,Macedo, Taís S.,Barbosa-Filho, José Maria,Soares, Milena B.P.,Batista, Alzir A.
, p. 33 - 39 (2014/05/06)
The present study describes the synthesis, characterization, antileishmanial and antiplasmodial activities of novel diimine/(2,2′- bipyridine (bipy), 1,10-phenanthroline (phen), 4,4′-methylbipyridine (Me-bipy) and 4,4′-methoxybipyridine (MeO-bipy)/phosphi
Ruthenium carbonyl compounds containing polypyridine ligands as catalysts in the reaction of N-benzylideneaniline hydrogenation
Moya,Vidal,Brown,Negrete-Vergara,Abarca,Aguirre
, p. 146 - 148 (2012/08/27)
The synthesis and characterization of ruthenium complexes containing polypyridine ligands: Ru(dppz)(PPh3)2Cl2, Ru(bpy)(PPh3)2Cl2, Ru(phen)(PPh 3)2Cl2, Ru(dppz-Cl)(PPh3) 2Cl2, Ru(phen)(CO)2Cl2, Ru(bpy)(CO)2Cl2 and Ru(dppz)(CO)2Cl2 (where dppz: dipyrido[3,2-a:2′,3′-c]phenazine, dppz-Cl: 10-chlororodypirido[3,2-a:2′,3′-c]phenazine, phen: 1,10-phenanthroline and bipy: 2,2′-bipyridine) are reported. The ruthenium complexes show high activity as catalysts in the hydrogenation reaction of N-benzylideneaniline and the hydrogen transfer reaction. The products of the catalysis were obtained with conversions between 21 and 91% after 2 h of reaction. The Ru(phen)(CO)2Cl2 complex was the catalyst that showed the highest conversion (91%) for the hydrogenation of N-benzylideneaniline. The complexes Ru(dppz)(PPh3)2Cl 2, Ru(bpy)(PPh3)2Cl2 and Ru(dppz)(CO)2Cl2 showed 99% conversion in the hydrogen transfer reaction.
Electrochemical and spectroscopic studies on RuCl2(PPh3)2(N)2 and RuCl2(PPh3)2(N-N) complexes (N = pyridine derivatives and N-N = phenanthroline or bipyridine derivatives). X-ray structure of RuCl2(PPh3)2(phen)
Batista, Alzir A.,Santiago, Marcelo O.,Donnici, Claudio L.,Moreira, Icaro S.,Healy, Peter C.,Berners-Price, Susan J.,Queiroz, Salete L.
, p. 2123 - 2128 (2008/10/08)
A series of RuCl2(PPh3)2(N)2 and RuCl2(PPh3)2(N-N) complexes were synthesized from RuCl2(PPh3)3, (N)2 = pyridine (py), 4-(N,N-dimethylamino)pyridine (4-dmNpy), 4-tert-butylpyridine (4-tBu-py), 4-methylpyridine (4-Mepy), 4-vinylpyridine (4-Vpy), 4-phenylpyridine (4-Phpy), isonicotinamide (4-CONH2py), 4-cyanopyridine (4-CNpy) N-N = 1,10-phenanthroline (phen), 2,2′-bipyridine (bipy), 2,2′-bipyridine-4,4′-dimethoxy (MeO-bipy), 2,2′-bipyridine-4,4′-dimethyl (Me-bipy), 2,2′-bipyridine-4,4′dithiomethyl (MeS-bipy), 2,2′-bipyridine-4,4′-dichloro (Cl-bipy) and 2,2′-bipyridine-4,4′-dinitro (NO2-bipy). The complexes were characterized by elemental analysis, cyclic voltammetry and UV-Vis, NMR and IR spectroscopies. The structure of the RuCl2(PPh3)2(phen) was established by single crystal X-ray crystallography.
