21627-62-3Relevant academic research and scientific papers
Cobalt(II) complexes of 4-(1-H-1,3-benzimidazole-2-yl)-1,5-dimethyl-2- phenyl-1-2-dihydro-3-H-pyrazol-3-one incorporating various anions: Synthesis, characterization and crystal structures
Kumar, P. M. Vimal,Radhakrishnan
experimental part, p. 2335 - 2344 (2010/09/06)
The structure of 4-(1-H-1,3-benzimidazole-2-yl)-1,5-dimethyl-2-phenyl-1-2- dihydro-3-H-pyrazol-3-one (Opdac) derived from the condensation of O-phenylenediamine and 4-antipyrine carboxaldehyde has been confirmed by X-ray crystallography. The free ligand, Opdac, crystallizes into a triclinic lattice with the space group P1?. Reaction of Opdac with salts of Co(II) affords five novel mononuclear complexes [Co(Opdac)Cl2] (1), [Co(Opdac)Br2] (2), [Co(Opdac)[2] (3), [Co(Opdac) 2NO3]NO3 (4) and [Co(Opdac)2ClO 4]-ClO4 (5). All the reaction products were characterized by a variety of physicochemical techniques, viz. elemental analysis, molar conductivity, CHNS analysis, magnetic susceptibility measurements and spectroscopic studies. The solid-state structures of complexes 1, 2 and 4 were established by Single Crystal X-ray crystallography. The complex 1 crystallize in the monoclinic space group C2/c, where as complex 2 crystallizes in the orthorhombic space group Pbca. In complexes 1 and 2, the ratio of metal to ligand is 1:1 and both the anions are coordinated to the metal ion, in which central metal ion adopts a distorted tetrahedral geometry. The mononuclear units in 1 and 2 are engaged in weak intermolecular C-H?X and N-H?X (X = Cl or Br) hydrogen bonds to give a 2D structure. The complex 4 crystallized in monoclinic space group C2/c forming six membered chelate ring. The structural analysis show that Co(II) ion in 4 adopts a distorted octahedral geometry with a CoN2O2 chromophore, ligated through two imine nitrogen and two pyrazolone oxygen atoms from two Opdac units; the hexacoordination is completed by O atom of the nitrate ion in a bidentate fashion. The hydrogen gas sorption isotherms at 77 K confirmed the permanent porosities of the complex 1.
Rapid and efficient synthesis of 4-substituted pyrazol-5-one under microwave irradiation in solvent-free conditions
Zahran, Magdy A.-H.,El-Essawy, Farag A.-A.,Yassin, Salah M.,Salem, Tarek A.-R.,Boshta, Nader M.
, p. 591 - 598 (2008/12/21)
New heterocyclic compounds containing pyrazol-5-one coupled with benzimidazole, benzothiazole, benzoxazole, quinoline, naphthyridin, and pyrazole were synthesized. Comparative investigations to synthesize these interesting classes of heterocyclic compounds through conventional heating or under microwave-irradiation conditions were presented. Synthesized compounds 1a, 2a, 4k, 3a, c, 5a, b, 6b, 7a, b, d, 8a, and 9a were evaluated for their antitumor activity. Some of these compounds exhibited promising antitumor activity.
