216386-24-2Relevant academic research and scientific papers
Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach
Beswick, Paul J.,Blackaby, Andrew P.,Bountra, Chas,Brown, Terry,Browning, Kerry,Campbell, Ian B.,Corfield, John,Gleave, Robert J.,Guntrip, Steve B.,Hall, Richard M.,Hindley, Sean,Lambeth, Paul F.,Lucas, Fiona,Mathews, Neil,Naylor, Alan,Player, Hazel,Price, Helen S.,Sidebottom, Phillip J.,Taylor, Nicholas L.,Webb, Graham,Wiseman, Joanne
scheme or table, p. 4509 - 4514 (2010/04/05)
Many years of work have been invested in the identification of potent and selective COX-2 inhibitors for the treatment of chronic inflammatory pain. One issue faced by workers is the balance between the lipophilicity required for potent enzyme inhibition
