216392-37-9

Upstream product

• 216392-34-6 1-[(tert-butoxycarbonyl)-L-(O-benzyl)tyrosyl]-3(R,S)-pyrrolidinol 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 

Downstream Products

• 216392-38-0 1-[(tert-butoxycarbonyl)-L-tyrosyl]-3-pyrrolidinone 

Relevant academic research and scientific papers

Use of proline bioisosteres in potential HIV protease inhibitors: Phenylalanine-2-thiophenoxy-3-pyrrolidinone: Synthesis and anti-HIV evaluation

The synthesis of new phenylalanine-2-thiophenoxy-3-pyrrolidinones is described. Anti-HIV recombinant protease assays and HIV infected cell culture assays (observation of syncytia) demonstrated the potent anti-HIV activity of this new class of pseudopeptides. (C) 2000 Published by Elsevier Science Ltd.

Short and unexpectedly potent 3-pyrrolidinone type inhibitors of HIV-1 replication

Based on the specific PhePro proteolytic cleavage of the HIV protease, short pseudo-peptides incorporating a 3-pyrrolidinone none ring have been synthesized. Their potencies to inhibit HIV-1 in MT4 cell culture have been evaluated and compared to that of the bioisostere dipeptide BocPhePro. Analogues incorporating an aromatic residue have shown to inhibit HIV-1 infection in MT4 human lymphoid cell with an IC50 ranging from 1 to 10 μM. Further experiments are in progress to determine their HIV protease inhibition properties.