2164-33-2

Usage

Uses

Used in Pharmaceutical Industry:
2-(CHLOROMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE is used as a synthetic intermediate for the production of various pharmaceutical compounds. Its unique structure allows for the creation of a wide range of benzene-based drugs with potential therapeutic applications.
Used in Chemical Synthesis:
2-(CHLOROMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE is used as a reactant in the synthesis of various organic compounds, such as benzenesulfonamide derivatives. Its reactivity and versatility make it a valuable building block for the development of new chemical entities with diverse applications.
Used in Research and Development:
In the field of research and development, 2-(CHLOROMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE serves as a key compound for exploring new reaction pathways and developing innovative synthetic methods. Its unique properties can be harnessed to design and synthesize novel molecules with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.

InChI:InChI=1/C9H9ClO2/c10-5-7-6-11-8-3-1-2-4-9(8)12-7/h1-4,7H,5-6H2

Upstream product

• 96-23-1 1,3-Dichloro-2-propanol 
• 120-80-9 benzene-1,2-diol 
• 3663-82-9 2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin 
• 533-58-4 2-Iodophenol 
• 106-89-8 epichlorohydrin 

Downstream Products

• 59-39-2 Piperoxan 
• 34274-18-5 4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-morpholine 
• 1044-59-3 1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-4-phenyl-piperazine 
• 21398-65-2 (2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-propyl-amine 
• 4442-62-0 (2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-isobutyl-amine 
• 21398-66-3 ethyl-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-amine 
• 4442-63-1 (2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-pentyl-amine 
• 91246-67-2 2-Dimethylaminomethyl-1,4-benzodioxan 
• 21398-64-1 (2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-isopropyl-amine 
• 952-37-4 prosympal 
• 4442-60-8 butyl-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-amine 
• 113061-08-8 (+/-)-1-(2-chloromethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-3t-phenyl-propenone 
• 98765-41-4 (+/-)-1-(3-chloromethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-3t-phenyl-propenone 
• 52186-28-4 2-[ethyl-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-amino]-ethanol 

Relevant academic research and scientific papers

A sulfuric acid guanidine lives synthesis method

The invention belongs to the technical field of organic drug synthesis, and particularly relates to a guanoxan sulfate synthesis method. The method comprises steps as follows: 1), 2-hydroxymethyl-1,4-benzodioxane and thionyl chloride have a chlorination reaction under the condition of existence of a solvent I, and 2-chloromethyl-1,4-benzodioxane is obtained; 2), 2-chloromethyl-1,4-benzodioxane and guanidine are condensed under the condition of existence of alkali and a solvent II, guanoxan is obtained, guanoxan and sulfuric acid are salified, and a finished product guanoxan sulfate is obtained. According to the guanoxan sulfate synthesis method, technological synthesis steps are simple, a route is short, raw material toxicity is relatively lower, and the yield and the purity of the product are high.

Alumina-supported Cu(II), A versatile and recyclable catalyst for regioselective ring opening of aziridines and epoxides and subsequent cyclization to functionalized 1,4-benzoxazines and 1,4-benzodioxanes

An easily accessible catalyst, alumina-supported copper(II), efficiently catalyzes the ring opening of aziridines and epoxides followed by cyclization of the corresponding intermediate to produce a variety of functionalized 1,4-benzoxazines and 1,4-benzodioxanes, respectively, in one pot without any ligand in high yields. The ring cleavages of aziridines and epoxides are highly regioselective. The catalyst is inexpensive, non-air-sensitive, environmentally friendly, and recyclable. The function of the catalyst and the reaction pathway are postulated. This protocol is successfully utilized for the formation of three carbon-heteroatom bonds, namely, C-O, C-N, and C-S, in one pot.

Anti-hypertensive benzodioxan derivatives

This invention relates to benzodioxanylalkylpiperidines, to processes for producing them and to the pharmaceutical compositions containing such compounds as active ingredient. This invention also relates to a method for treating hypertension in hypertensive mammals.

Neuroleptic n-oxacyclyl-alkylpiperidine derivatives

Neuroleptically active compounds of the formula STR1 wherein R6 and R10 are --H or CH3 ; R7 and R8 are independently --H, --F, --Cl, or --CH3 ; and R9 is --F, --Cl, --CH3, or --OCH3.