2164-33-2

Basic information

• Product Name: 2-(CHLOROMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE
• Synonyms: 2-CHLOROMETHYL-1,4-BENZODIOXANE;2-(CHLOROMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE;2-CHLOROMETHYL-2,3-DIHYDRO-BENZO[1,4]DIOXINE;TIMTEC-BB SBB010127;2-(chloromethyl)-2,3-dihydro-1,4-benzodioxin;1,4-Benzodioxin, 2-(chloromethyl)-2,3-dihydro-;2-(CHLOROMETHYL)-1,4-BENZODIOXAN;2-(chloromethyl)-2,3-dihydrobenzo[b][1,4]dioxine
• CAS NO: 2164-33-2
• Molecular Formula: C₉H₉ClO₂
• Molecular Weight: 184.62
• EINECS: 218-502-5
• Mol File: 2164-33-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 96 °C
• Flash Point: 96°C/0.4mm
• Appearance: /
• Density: 1.224g/cm³
• Vapor Pressure: 0.0116mmHg at 25°C
• Refractive Index: 1.5540
• BRN: 150153
• CAS DataBase Reference: 2-(CHLOROMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE(2164-33-2)
• EPA Substance Registry System: 2-(CHLOROMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE(2164-33-2)

Safety Data

• Hazard Codes: Xi
• Statements: R34:Causes burns.
• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 2164-33-2(Hazardous Substances Data)

Usage

Uses

2-(chloromethyl)-2,3-dihydro-1,4-benzodioxine is a useful reactant for the synthesis of various organic compounds such as benzenesulfonamide derivatives.

InChI:InChI=1/C9H9ClO2/c10-5-7-6-11-8-3-1-2-4-9(8)12-7/h1-4,7H,5-6H2

Upstream product

• 96-23-1 1,3-Dichloro-2-propanol 
• 120-80-9 benzene-1,2-diol 
• 533-58-4 2-Iodophenol 
• 106-89-8 epichlorohydrin 
• 3663-82-9 2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin 

Downstream Products

• 59-39-2 Piperoxan 
• 34274-18-5 4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-morpholine 
• 113114-54-8 (2RS,3SR)-2,3-dibromo-1-((Ξ)-3-chloromethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-3-phenyl-propan-1-one 
• 113061-06-6 (2RS,3SR)-2,3-dibromo-1-((Ξ)-2-chloromethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-3-phenyl-propan-1-one 
• 132962-26-6 3-(2-chloromethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-phenyl-4,5-dihydro-1H-pyrazole; hydrochloride 
• 132962-25-5 3-(3-chloromethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-phenyl-4,5-dihydro-1H-pyrazole; hydrochloride 
• 119640-90-3 1-(2-chloromethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-3-phenyl-propan-1-one-(2,4-dinitro-phenylhydrazone) 
• 111589-18-5 1-[7-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl]-piperidine 
• 120855-58-5 1-[7-(1,5-diphenyl-4,5-dihydro-1H-pyrazol-3-yl)-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl]-piperidine 
• 123965-65-1 1-[6-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl]-piperidine 
• 123936-79-8 1-[7-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl]-piperidine 
• 116606-03-2 3-phenyl-1-(3-piperidinomethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-propenone 
• 116976-09-1 3-phenyl-1-(2-piperidinomethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-propenone 
• 116665-53-3 3-(3-chloromethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl)-1,5-diphenyl-4,5-dihydro-1H-pyrazole 

Relevant articles and documents

A sulfuric acid guanidine lives synthesis method

The invention belongs to the technical field of organic drug synthesis, and particularly relates to a guanoxan sulfate synthesis method. The method comprises steps as follows: 1), 2-hydroxymethyl-1,4-benzodioxane and thionyl chloride have a chlorination reaction under the condition of existence of a solvent I, and 2-chloromethyl-1,4-benzodioxane is obtained; 2), 2-chloromethyl-1,4-benzodioxane and guanidine are condensed under the condition of existence of alkali and a solvent II, guanoxan is obtained, guanoxan and sulfuric acid are salified, and a finished product guanoxan sulfate is obtained. According to the guanoxan sulfate synthesis method, technological synthesis steps are simple, a route is short, raw material toxicity is relatively lower, and the yield and the purity of the product are high.

Research on the calcium inhibition of a heterocyclic oxygen compound series

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Neuroleptic n-oxacyclyl-alkylpiperidine derivatives

Neuroleptically active compounds of the formula STR1 wherein R6 and R10 are --H or CH3 ; R7 and R8 are independently --H, --F, --Cl, or --CH3 ; and R9 is --F, --Cl, --CH3, or --OCH3.