216527-69-4Relevant academic research and scientific papers
Novel biferrocene-based phosphoramidite ligands: The combination of a rather unexplored chiral backbone and a privileged ligand scaffold
Kimpe,Janssens,Bert,Wackens,Goeman,Van der Eycken
, (2019)
A small library of novel chiral monodentate phosphoramidite ligands, characterized by a dihydroazepine-biferrocene backbone was prepared. In order to obtain this biferrocene substructure, a mild and efficient homocoupling was developed. This allowed to synthesize the dihydroazepine ligand precursor and the phosphoramidite ligands with good overall yields and high enantiomeric excess. These ligands were successfully tested in a rhodium(I)-catalyzed hydrogenation of activated olefins.
