216586-54-8

Basic information

• Product Name: 2-((1R,2R)-2-hydroxycyclohexyl)-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-((1R,2R)-2-hydroxycyclohexyl)-1H-isoindole-1,3(2H)-dione
• CAS NO: 216586-54-8
• Molecular Weight: 245.278
• Mol File: 216586-54-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-((1R,2R)-2-hydroxycyclohexyl)-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((1R,2R)-2-hydroxycyclohexyl)-1H-isoindole-1,3(2H)-dione(216586-54-8)
• EPA Substance Registry System: 2-((1R,2R)-2-hydroxycyclohexyl)-1H-isoindole-1,3(2H)-dione(216586-54-8)

Safety Data

• Hazardous Substances Data: 216586-54-8(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 5399-20-2 2-(2-hydroxy-cyclohexyl)-isoindole-1,3-dione 
• 931-16-8 (+/-)-trans-2-aminocyclohexanol 

Downstream Products

• 931-15-7 (1R,2R)-2-aminocyclohexanol 

Relevant articles and documents

Cyclic trans-β-amino alcohols: Preparation and enzymatic kinetic resolution

Enantioenriched cyclic β-amino alcohols, trans-2-aminocyclohexanols (ee, >99%), trans-2-aminocyclopentanols (ee, >99%), trans-1-amino-2- indanols (ee, >99%) and trans-2-amino-1-indanols (ee, ～98%) were prepared in high yields via an Arthrobacter sp. Lipase/PLAP catalyzed kinetic resolution of racemic phthalimido acetates. The addition of toluene as a co-solvent dramatically improved the hydrolysis and enantioselectivity, whereas for indanols, substrate immobilization on Celite improved the efficacy of the kinetic resolution.