2166-08-7Relevant academic research and scientific papers
Solid phase synthesis of pyridazine derivatives using polymer-bound sodium benzenesulfinate
Chen, Yu,Lam, Yulin,Lee, Soo-Ying
, p. 274 - 275 (2001)
A new solid phase synthesis of 3,6-disubstituted pyridazine derivatives, resulting from the reaction of polymer-bound sodium benzenesulfinate with α-bromoketone substrates followed by condensation with hydrazine, is described. Mild basic conditions for the condensation reaction simultaneously release the desired product from the solid support. The crystal structure of 3,6-bis(p-chlorophenyl)pyridazine is reported.
