216656-55-2Relevant academic research and scientific papers
INHIBITORS OF SARS COV-2 INFECTION AND USES THEREOF
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, (2022/03/09)
Provided herein are pharmaceutical compositions including compounds having Formula I (I) in an effective amount to inhibit non-viral cysteine protease (e.g., mammalian cysteine protease, such as human cathepsin L), as well as methods of using thereof.
Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: Design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition
Capela, Rita,Oliveira, Rudi,Goncalves, Lidia M.,Domingos, Ana,Gut, Jiri,Rosenthal, Philip J.,Lopes, Francisca,Moreira, Rui
scheme or table, p. 3229 - 3232 (2010/05/02)
A series of artemisinin-vinyl sulfone hybrid molecules with the potential to act in the parasite food vacuole via endoperoxide activation and falcipain inhibition was synthesized and screened for antiplasmodial activity and falcipain-2 inhibition. All conjugates were active against the Plasmodium falciparum W2 strain in the low nanomolar range and those containing the Leu-hPhe core inhibited falcipain-2 in low micromolar range.
