216659-47-1

Basic information

• Product Name: Carbamic acid, [3-(dimethylamino)propyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [3-(dimethylamino)propyl]-, 1,1-dimethylethyl ester (9CI);Tert-Butyl3-(dimethylamino)propylcarbamate
• CAS NO: 216659-47-1
• Molecular Formula: C₁₀H₂₂N₂O₂
• Molecular Weight: 202.29388
• Product Categories: N-BOC
• Mol File: 216659-47-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 287.882°C at 760 mmHg
• Flash Point: 127.906°C
• Appearance: /
• Density: 0.948±0.06 g/cm3(Predicted)
• Vapor Pressure: 0.001mmHg at 25°C
• PKA: 12.80±0.46(Predicted)
• CAS DataBase Reference: Carbamic acid, [3-(dimethylamino)propyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [3-(dimethylamino)propyl]-, 1,1-dimethylethyl ester (9CI)(216659-47-1)
• EPA Substance Registry System: Carbamic acid, [3-(dimethylamino)propyl]-, 1,1-dimethylethyl ester (9CI)(216659-47-1)

Safety Data

• Hazardous Substances Data: 216659-47-1(Hazardous Substances Data)

Usage

General Description

Carbamic acid, [3-(dimethylamino)propyl]-, 1,1-dimethylethyl ester (9CI) is a chemical compound commonly known as tert-butyl 3-(dimethylamino)propylcarbamate. It is an ester of carbamic acid and is often used as an intermediate in the synthesis of pharmaceuticals. This chemical is a clear, colorless liquid with a faint odor and is insoluble in water. It is primarily used in the pharmaceutical industry for the production of various drugs and medications. However, it is important to handle this chemical with care and follow proper safety protocols when working with it, as it is classified as a hazardous material.

InChI:InChI=1/C10H22N2O2/c1-10(2,3)12(9(13)14)8-6-7-11(4)5/h6-8H2,1-5H3,(H,13,14)/p-1

Upstream product

• 762-75-4 tert-butyl formate 
• 109-55-7 1-amino-3-(dimethylamino)propane 
• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

Membrane active vancomycin analogues: A strategy to combat bacterial resistance

The alarming growth of antibiotic resistant superbugs such as vancomycin-resistant Enterococci and Staphylococci has become a major global health hazard. To address this issue, we report the development of lipophilic cationic vancomycin analogues possessing excellent antibacterial activity against several drug-resistant strains. Compared to vancomycin, efficacy greater than 1000-fold was demonstrated against vancomycin-resistant Enterococci (VRE). Significantly, unlike vancomycin, these compounds were shown to be bactericidal at low concentrations and did not induce bacterial resistance. An optimized compound in the series, compared to vancomycin, showed higher activity in methicillin-resistant Staphylococcus aureus (MRSA) infected mouse model and exhibited superior antibacterial activity in whole blood with no observed toxicity. The remarkable activity of these compounds is attributed to the incorporation of a new membrane disruption mechanism into vancomycin and opens up a great opportunity for the development of novel antibiotics.

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Hydrophobically modified sulfobetaine copolymers with tunable aqueous UCST through postpolymerization modification of poly(pentafluorophenyl acrylate)

Polysulfobetaines, polymers carrying highly polar zwitterionic side chains, present a promising research field by virtue of their antifouling properties, hemocompatibility, and stimulus-responsive behavior. However, limited synthetic approaches exist to produce sulfobetaine copolymers comprising hydrophobic components. Postpolymerization modification of an activated ester precursor, poly(pentafluorophenyl acrylate), employing a zwitterionic amine, 3-((3-aminopropyl)dimethylammonio)propane-1-sulfonate, ADPS, is presented as a novel, one-step synthetic concept toward sulfobetaine (co)polymers. Modifications were performed in homogeneous solution using propylene carbonate as solvent with mixtures of ADPS and pentylamine, benzylamine, and dodecylamine producing a series of well-defined statistical acrylamido sulfobetaine copolymers containing hydrophobic pentyl, benzyl, or dodecylacrylamide comonomers with well-controllable molar composition as evidenced by NMR and FT-IR spectroscopy and size exclusion chromatography. This synthetic strategy was exploited to investigate, for the first time, the influence of hydrophobic modification on the upper critical solution temperature (UCST) of sulfobetaine copolymers in aqueous solution. Surprisingly, incorporation of pentyl groups was found to increase solubility over a wide composition range, whereas benzyl groups decreased solubility - an effect attributed to different entropic and enthalpic contributions of both functional groups. While UCST transitions of polysulfobetaines are typically limited to higher molar mass samples, incorporation of 0-65 mol % of benzyl groups into copolymers with molar masses of 25.5-34.5 kg/mol enabled sharp, reversible transitions from 6 to 82 C in solutions containing up to 76 mM NaCl, as observed by optical transmittance and dynamic light scattering. Both synthesis and systematic UCST increase of sulfobetaine copolymers presented here are expected to expand the scope and applicability of these smart materials.

Interfacial tetrazine click chemistry mediated assembly of multifunctional colloidosomes

We demonstrate that tetrazine ligation chemistry can be employed to cross-link and assemble gold nanoparticles at the water-oil interface to create plasmonic colloidosomes. These biocompatible colloidosomes exhibit size tunabilityviacontrollable ligation kinetics and display high encapsulation efficiency, size-selective permeability, and surface-enhanced Raman scattering (SERS)-based sensing modality.

CHEMICAL BLOWING AGENT AND THERMALLY EXPANDABLE THERMOPLASTIC COMPOSITION

The present invention relates to a chemical blowing agent comprising at least one tertiary alkyl carbamate. The chemical blowing agent can be activated thermally and is suitable for foaming thermoplastic materials and can for example be incorporated into thermally expandable baffle and/or reinforcement elements which are used in automotive manufacturing and building insulation.