216691-13-3Relevant academic research and scientific papers
(-)3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: A dual PPAR agonist with potent antihyperglycemic and lipid modulating activity
Lohray,Lohray,Bajji,Kalchar,Poondra,Padakanti,Chakrabarti,Vikramadithyan,Misra,Juluri,Mamidi,Rajagopalan
, p. 2675 - 2678 (2001)
(-)DRF 2725 (6) is a phenoxazine analogue of phenyl propanoic acid. Compound 6 showed interesting dual activation of PPARα and PPARγ. In insulin resistant db/db mice, 6 showed better reduction of plasma glucose and triglyceride levels as compared to rosig
New PPARγ ligands based on barbituric acid: Virtual screening, synthesis and receptor binding studies
Sundriyal, Sandeep,Viswanad, Bhoomi,Ramarao, Poduri,Chakraborti, Asit K.,Bharatam, Prasad V.
scheme or table, p. 4959 - 4962 (2009/05/30)
A new series of PPARγ ligands based on barbituric acid (BA) has been designed employing virtual screening and molecular docking approach. To validate the computational approach, designed molecules were synthesized and evaluated in in vitro radioligand bin
