216754-32-4

Upstream product

• 90319-52-1 (4R)-phenyl-2-oxazolidinone 
• 451-81-0 2-(2-fluorophenyl)acetyl chloride 
• 41233-93-6 potassium 2-methylbutan-2-olate 
• 451-82-1 (2-fluorophenyl)acetic acid 

Downstream Products

• 472985-79-8 2-fluoro-α-[[[bis(ethoxycarbonyl)methyl]amino]methylidenyl]-β-(R)-[(triphenylmethoxy)methyl]benzenepropionitrile 
• 472985-80-1 ethyl 3-amino-4-[1-(2-fluorophenyl)-2-(R)-(triphenylmethoxy)ethyl]-2-1H-pyrrole-2-carboxylate 
• 472985-78-7 2-fluoro-α-(hydroxymethylidenyl)-β-(R)-[(triphenylmethoxy)methyl]benzenepropionitrile 
• 778570-09-5 4-[1-(2-fluoro-phenyl)-2-hydroxy-ethyl]-3-guanidino-1H-pyrrole-2-carboxylic acid ethyl ester 
• 472985-77-6 2-fluoro-β-(R)-[(triphenylmethyl)oxy]benzenepropionitrile 
• 472985-81-2 3-amino-4-[1-(2-fluoro-phenyl)-2-hydroxy-ethyl]-1H-pyrrole-2-carboxylic acid ethyl ester 
• 214492-07-6 2-fluoro-(β-(S)-hydroxymethyl)benzenepropionitrile 
• 214492-06-5 2-fluoro-(β-(R)-hydroxymethyl)benzenepropionitrile 
• 214491-95-9 β-(R)-(2-fluorophenyl)-γ,2-dioxo-4-(R)-phenyl-3-oxazolidinebutyronitrile 
• 214491-99-3 β-(S)-(2-fluorophenyl)-γ,2-dioxo-4-(R)-phenyl-3-oxazolidinebutyronitrile 

Relevant academic research and scientific papers

An efficient and large-scale enantioselective synthesis of PNP405: A purine nucleoside phosphorylase inhibitor

An efficient and large-scale enantioselective synthesis of PNP405 (1), a purine nucleoside phosphorylase inhibitor, is described. This synthesis of 1 involved eight steps starting from o-fluorophenylacetic acid with a 21.6% overall yield and >99.5% enantiopurity. The key stereogenic center with (R)-configuration was created using Evans' asymmetric alkylation methodology. This synthesis also features the racemization-free reductive removal of the chiral auxiliary in 5 using sodium borohydride, protection of the γ-cyano alcohol 6 as the trityl ether by a new water-assisted tritylation with trityl chloride and triethylamine or with trityl alcohol and catalytic trifluoroacetic acid, and an efficient one-pot cyclo-guanidinylation of 10 using cyanamide as the guanidinylating agent.

2-amino-7-(1-substituted-2-hydroxyethyl)-3,5-dihydropyrrolo[3,2-D]pyrimidin-4-ones

The invention relates to the 2-amino-7-(1-substituted-2-hydroxyethyl)-3, 5-dihydro-pyrrolo[3,2-d] pyrimidin-4-ones of formula I and tautomers thereof, wherein Ar represents biaryl, carbocyclic or heterocyclic aryl; pharmaceutically acceptable prodrug este

Preparation of 2-amino-7-(1-substituted-2-hydroxyethyl)-3, 5-dihydropyrrolo[3,2-d]pyrimidin-4-ones

The compounds of formula I wherein Ar represents biaryl, carbocyclic or heterocyclic aryl, are prepared, as substantially pure enantiomers, by (a) condensing a compound of the formula as a substantially pure enantiomer, wherein Ar has meaning as defined a

A convenient and practical method for N-acylation of 2 oxazolidinone chiral auxiliaries with acids

A one-pot, convenient and practical method for N-acylation of 2- oxazolidinone chiral auxiliaries directly with acids in the presence of pivaloyl chloride and triethylamine is described.