216760-89-3

Basic information

• Product Name: Bis-[4-(3-bromo-propoxy)-phenyl]-diazene
• Synonyms: Bis-[4-(3-bromo-propoxy)-phenyl]-diazene
• CAS NO: 216760-89-3
• Molecular Weight: 456.177
• Mol File: 216760-89-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Bis-[4-(3-bromo-propoxy)-phenyl]-diazene(CAS DataBase Reference)
• NIST Chemistry Reference: Bis-[4-(3-bromo-propoxy)-phenyl]-diazene(216760-89-3)
• EPA Substance Registry System: Bis-[4-(3-bromo-propoxy)-phenyl]-diazene(216760-89-3)

Safety Data

• Hazardous Substances Data: 216760-89-3(Hazardous Substances Data)

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 2050-16-0 4,4'-dihydroxyazobenzene 
• 123-30-8 4-amino-phenol 

Downstream Products

• 141484-77-7 C₄₄H₃₆N₄O₄ 

Relevant articles and documents

New heterocyclic tetrathiafulvalene compounds with an azobenzene moiety: Photomodulation of the electron-donating ability of the tetrathiafulvalene moiety

(Chemical Equation Presented) New heterocyclic TTF compounds 1a-c and 2 with an azobenzene moiety were described. The oxidation potential of 1a could be reversibly modulated by alternating UV and visible light irradiation. As a result, a molecular switch

New photochromic azoderivatives with potent acetylcholinesterase inhibition

The design of photochromic cholinesterase inhibitors is a challenge of the photopharmacological approach towards the remote control of acetylcholinesterase (AChE) enzyme and its potential application in Alzheimer's disease therapy. In this work, a series of azoderivatives were designed, synthesized and evaluated as AChE inhibitors. The optimized microwave-assisted synthesis (two steps) showed excellent yields with a total reaction time no longer than 40 min. The results showed that all the synthesized compounds exhibited high AChE inhibitory activity at the micromolar range (IC50, 0.65–8.52 μM). Moreover, compound 19, with double four-hydrocarbon chain connected to piperidine, showed a powerful in vitro enzymatic response for its Z isomer (IC50: 0.43 μM) determined by Ellman's assay. Also, 19 showed a stable photostationary state monitored by UV/Vis absorption spectroscopy and 1H NMR spectra. These results indicate that 19 can act as an efficient photo-responsible probe to remote control AChE activity. Molecular modelling analysis of 19 Z revealed its affinity by the peripheral anionic site of AChE, providing understanding of its higher inhibition power. This study contributes to the development of new promising agents for photopharmacological treatment of Alzheimer's disease.