21679-78-7Relevant academic research and scientific papers
SERIES OF SEQUENTIAL POLYPEPTIDES CONTAINING LYSINE OR ARGININE: PREPARATION AND CHARACTERIZATION
Pirkova, Jana,Churkina, Svetlana,Gut, Vladimir,Fric, Ivo,Blaha, Karel
, p. 145 - 156 (2007/10/02)
The sequential polypeptides (Lys-Ala)n, (Lys-Ala-Ala)n, (lys-Ala-Ala-Ala)n, (Lys-Leu-Ala)n, (Lys-Leu-Ala-Ala)n, (Lys-Leu-Ala-Ala-Ala)n, (lys-Ala-Leu)n, (lys-Ala-Leu-Ala)n, (Orn-Leu-Ala)n, (Arg-Ala-Ala)n, (Arg-Leu-Ala)n, (Arg-Leu-Ala-Ala)n, (Arg-Ala-Leu)n, and (Arg-Ala-Leu-Ala)n were synthesized by polymerization of active esters (1-succinimidyl or pentafluorophenyl) of the corresponding Nα-deblocked monomers.The monomers were prepared using the usual methods of peptide synthesis in solution.Upon dialysis, the average molecular weight of the polymers was 6 000-9 000 as determined by sedimentation in ultracentrifuge.Polypeptides, contaning leucine in addition to the basic amino acid, showed a marked tendency to aggregation.CD spectra of the products were measured for characterization.
