216854-25-0

Usage

Structure

A derivative of isoindole-1,3(2H)-dione with a 2-(2-methoxyphenyl)-2-oxoethyl group.

Physical form

White to off-white crystalline powder.

Pharmacological properties

Potential pharmacological properties and used in pharmaceutical research and development.

Applications

Wide range of applications in the pharmaceutical industry as a potential therapeutic agent for various medical conditions.

Upstream product

• 31949-21-0 bromomethyl 2-methoxyphenyl ketone 
• 1074-82-4 potassium phtalimide 
• 136918-14-4 phthalimide 
• 1121543-12-1 α,α-dibromo-2'-methoxyacetophenone 

Downstream Products

• 72481-17-5 2-amino-1-(2-hydroxy-phenyl)-ethanone 

Relevant academic research and scientific papers

Highly Enantioselective Asymmetric Hydrogenation of α-Phthalimide Ketone: An Efficient Entry to Enantiomerically Pure Amino Alcohols

A new type of α-phthalimide ketones was hydrogenated in excellent enantioselectivity by using a Ru-(C3-TunePhos) complex as the catalyst. Up to 10000 turnovers have been achieved in more than 99% ee in the hydrogenation reaction. A dynamic kinetic resolution study for the synthesis of threonine was performed, and high anti selectivity (>97:3) was observed for the first time. An efficient method to synthesize enantiomerically pure amino alcohols has been developed. Copyright

Bromophilic substitution/carbophilic substitution cascade reactions of α,α-dibromo-2-methoxyacetophenone with C-, N- and O-nucleophiles

α,α-Dibromo-2-methoxyacetophenone reacts, under mild reaction conditions, with C-, N- and O-nucleophiles via a bromophilic substitution/protonation/carbophilic substitution cascade process to afford α-monosubstituted-2-methoxyacetophenones in moderate to good yield. The only exception from this reaction pathway is the reaction with the anion derived from malononitrile in which 2-aroyl-1,1,3,3-tetracyanopropene is obtained.

Palladium-catalyzed asymmetric hydrogenation of functionalized ketones

(Chemical Equation Presented) A novel catalytic system for asymmetric hydrogenation of functionalized ketones has been developed using a Pd/bisphosphine complex as the catalyst in 2,2,2-trifluoroethanol. The reaction exhibits high enantioselectivity, and

A convenient one-pot synthesis of 4-amino-3-arylpyrazoles from α- phthaloylaminoacetophenones

Condensation of α-phthaloylaminoacetophenones 1a-c with N,N- dimethylformamide dimethyl acetal afforded the novel enamines 3a-c. Cyclization of 3 with hydrazine, alkylhydrazine or phenylhydrazine salts (4a- d) gave 4-phthaloylamino-3-arylpyrazoles 7-9 in