216854-38-5

Upstream product

• 60-34-4 methylhydrazine 
• 70-11-1 α-bromoacetophenone 
• 1032-67-3 N-benzoylmethylphthalimide 

Downstream Products

• 873581-64-7 C₁₆H₂₁N₃O₂ 
• 96256-48-3 3-methyl-1-phenyl-5-(trifluoromethyl)-1H-pyrazole 
• 873581-63-6 tert-butyl (1-methyl-3-phenyl-1H-pyrazol-4-yl)carbamate 

Relevant academic research and scientific papers

HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to heterocycle substituted amino-pyridine compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

A convenient one-pot synthesis of 4-amino-3-arylpyrazoles from α- phthaloylaminoacetophenones

Condensation of α-phthaloylaminoacetophenones 1a-c with N,N- dimethylformamide dimethyl acetal afforded the novel enamines 3a-c. Cyclization of 3 with hydrazine, alkylhydrazine or phenylhydrazine salts (4a- d) gave 4-phthaloylamino-3-arylpyrazoles 7-9 in