216863-16-0Relevant academic research and scientific papers
Synthesis of phosphino oxazoline ligand libraries from amino acid and phosphino carboxylate building blocks
Gilbertson, Scott R.,Chang, Cheng-Wei T.
, p. 8424 - 8431 (2007/10/03)
A modular route to new phosphine-oxazoline ligands is reported. The ability of these ligands to asymmetrically catalyze the addition of dimethyl malonate to 1,3-diphenylprop-2-enyl acetate was investigated. The best of these ligands gave a palladium complex which catalyzed the addition of dimethyl malonate to 1,3-diphenylprop-2-enyl acetate in a 99% yield and in 98% enantiomeric excess (Table 3, entry 11).
