216869-41-9

Upstream product

• 168828-74-8 (R)-<3-<3-fluoro-4-(4-thiomorpholinyl)phenyl>-2-oxo-5-oxazolidinyl>methyl azide 
• 121-51-7 3-nitrobenzenesulphonyl chloride 
• 216869-40-8 (R)-3-[4-(1,1-Dioxo-1λ⁶-thiomorpholin-4-yl)-3-fluoro-phenyl]-5-hydroxymethyl-oxazolidin-2-one 
• 268208-97-5 (R)-5-azidomethyl-3-[4-(1,1-dioxo-4-thiomorpholinyl)-3-fluorophenyl]oxazolidine-2-one 

Downstream Products

• 641635-04-3 N-({(5S)-3-[4-(1,1-dioxidothiomorpholin-4-yl)-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)-2,2-difluoroacetamide 
• 268209-34-3 (R)-3-[4-(1,1-Dioxo-1λ⁶-thiomorpholin-4-yl)-3-fluoro-phenyl]-5-isothiocyanatomethyl-oxazolidin-2-one 

Relevant academic research and scientific papers

Oxazolidinone antibacterial agents having a thiocarbonyl functionality

The present invention provides compounds of Formula 1: or pharmaceutical acceptable salts thereof wherein A, G and R1are as defined in the claims which are antibacterial agents.

Structure-activity relationship (SAR) studies on oxazolidinone antibacterial agents. 2.1) Relationship between lipophilicity and antibacterial activity in 5-thiocarbonyl oxazolidinones

5-Thiourea and 5-dithiocarbamate oxazolidinones were synthesized as a continuation of research on 5-thiocarbonyl oxazolidinone antibacterial agents considering the hydrophobic parameters of the molecule. The structure-activity relationship (SAR) study revealed that the antibacterial activity on 5-thiocarbonyl oxazolidinones was significantly affected by the lipophilicity, especially the calculated log P value and the balance between 5-hydrophilic (or hydrophobic) substituent and hydrophobic (or hydrophilic) substituents on the benzene ring. Some of 5-thiocarbonyl oxazolidinones were found to have good in vitro antibacterial activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).