216870-24-5

Basic information

• Product Name: Piperidine-1-carboxylic acid, 4-diethoxyphosphoryl ethyl ester
• Synonyms: 4 piperidine-1-carboxylic acid 4-diethoxyphosphoryl ethyl ester;Piperidine-1-carboxylic acid, 4-diethoxyphosphoryl ethyl ester;ethyl 4-(diethoxyphosphoryl)piperidine-1-carboxylate;4-(Diethoxyphosphoryl)-piperidine-1-carboxylic acid ethyl ester
• CAS NO: 216870-24-5
• Molecular Formula: C₁₂H₂₄NO₅P
• Molecular Weight: 293.296421
• Mol File: 216870-24-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Piperidine-1-carboxylic acid, 4-diethoxyphosphoryl ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine-1-carboxylic acid, 4-diethoxyphosphoryl ethyl ester(216870-24-5)
• EPA Substance Registry System: Piperidine-1-carboxylic acid, 4-diethoxyphosphoryl ethyl ester(216870-24-5)

Safety Data

• Hazardous Substances Data: 216870-24-5(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 541-41-3 chloroformic acid ethyl ester 
• 122-52-1 triethyl phosphite 
• 216870-07-4 4-(Diethoxy-phosphoryl)-4-hydroxy-piperidine-1-carboxylic acid ethyl ester 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 

Downstream Products

• 79794-75-5 loratadine 

Relevant articles and documents

NEW PROCESS FOR PREPARING LORATADINE FROM A KETONE INTERMEDIATE

This application is directed to a last step synthetic process for making loratadine from ketone intermediate.

Syntheses of novel piperidin-4-ylphosphinic acid, and piperidin-4-ylphosphonic acid analogues of the inhibitory neurotransmitter 4-aminobutyric acid (GABA)

Piperidin-4-ylphosphinic acid, methyl(piperidin-4-yl)phosphinic acid and piperidin-4-ylphosphonic acid analogues of the GABAA agonist piperidin-4-ylcarboxylic acid (isonipecotic acid) were synthesised. The acid groups were introduced using a sequential Pudovik addition followed by a Barton deoxygenation procedure and finally followed by acidic hydrolysis. The mild and efficient procedure gave the target amino acids in good yields.