216872-94-5Relevant academic research and scientific papers
Synthesis and evaluation of [123I] labeled iodovinyl amino acids syn-, anti-1-amino-3-[2-iodoethenyl]-cyclobutane-1-carboxylic acid, and 1-amino-3-iodomethylene-cyclobutane-1-carboxylic acid as potential SPECT brain tumor imaging agents
Yu, Weiping,Williams, Larry,Malveaux, Eugene,Camp, Vernon M.,Olson, Jeffrey J.,Goodman, Mark M.
, p. 1264 - 1268 (2008)
syn- and anti-1-amino-3-[2-iodoethenyl]-cyclobutane-1-carboxylic acid (syn-, anti-IVACBC 16, 17) and their analogue 1-amino-3-iodomethylene-cyclobutane-1-carboxylic acid (gem-IVACBC 18) were synthesized and radioiodoinated with [123I] in 34-43%
Discovery of pyrazinone based compounds that potently inhibit the drug-resistant enzyme variant R155K of the hepatitis C virus NS3 protease
Belfrage, Anna Karin,Abdurakhmanov, Eldar,?kerblom, Eva,Brandt, Peter,Oshalim, Anna,Gising, Johan,Skogh, Anna,Neyts, Johan,Danielson, U. Helena,Sandstr?m, Anja
supporting information, p. 2603 - 2620 (2016/06/08)
Herein, we present the design and synthesis of 2(1H)-pyrazinone based HCV NS3 protease inhibitors with variations in the C-terminus. Biochemical evaluation was performed using genotype 1a, both the wild-type and the drug resistant enzyme variant, R155K. S
Substituted cyclobutylamine derivatives
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, (2008/06/13)
Substituted cyclobutylamine derivativesb with a novel structure represented by the following formula (I), wherein R1to R4and Q each represents a specific substituent and, in particular, Q represents a quinolone derivative having a sp
