216883-23-7Relevant academic research and scientific papers
PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF
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Page/Page column 27, (2009/08/16)
The disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, and R5 are as defined in the disclosure, to the compositions containing them and to the use thereof as medicaments, in particular as anticancer agents. The disclosure also relates to the process for preparing the compounds of formula (I) and to reaction intermediates.
Identification of novel benzimidazole series of potent and selective ORL1 antagonists
Okamoto, Osamu,Kobayashi, Kensuke,Kawamoto, Hiroshi,Ito, Satoru,Satoh, Atsushi,Kato, Tetsuya,Yamamoto, Izumi,Mizutani, Sayaka,Hashimoto, Masaya,Shimizu, Atsushi,Sakoh, Hiroki,Nagatomi, Yasushi,Iwasawa, Yoshikazu,Takahashi, Hiroyuki,Ishii, Yasuyuki,Ozaki, Satoshi,Ohta, Hisashi
scheme or table, p. 3278 - 3281 (2009/04/05)
Structure-activity studies on benzimidazole lead 1 obtained from library screening led to the discovery of potent and selective ORL1 antagonist 28, 5-chloro-2-[(1-ethyl-1-methylpropyl)thio]-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1H-benzimidazole, which is s
