2169-46-2Relevant articles and documents
Synthesis of metergoline analogues and their evaluation as antiplasmodial agents
Singh, Kawaljit,Kaur, Gurminder,Mjambili, Faith,Smith, Peter J.,Chibale, Kelly
, p. 165 - 170 (2014)
A series of compounds based on metergoline were synthesized and evaluated in vitro for their antiplasmodial activity against the chloroquine-sensitive NF54 strain of the malaria parasite Plasmodium falciparum. These compounds were also screened for their cytotoxicity towards a mammalian cell line. Some of the compounds exhibited superior antiplasmodial activity with a good selectivity index relative to metergoline.