216959-94-3

Basic information

• Product Name: 4-(2-AMino-4-thiazolyl)benzoic Acid
• Synonyms: 4-(2-AMino-4-thiazolyl)benzoic Acid
• CAS NO: 216959-94-3
• Molecular Formula: C₁₀H₈N₂O₂S
• Molecular Weight: 220.24772
• Mol File: 216959-94-3.mol

Chemical Properties

• Boiling Point: 484.9±28.0 °C(Predicted)
• Appearance: /
• Density: 1.446±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.11±0.10(Predicted)
• CAS DataBase Reference: 4-(2-AMino-4-thiazolyl)benzoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-AMino-4-thiazolyl)benzoic Acid(216959-94-3)
• EPA Substance Registry System: 4-(2-AMino-4-thiazolyl)benzoic Acid(216959-94-3)

Safety Data

• Hazardous Substances Data: 216959-94-3(Hazardous Substances Data)

Usage

Properties

1. Chemical Formula: C11H9N3O2S
2. Derivative of: Tyrosine
3. Usage: Intermediate in pharmaceutical and agrochemical synthesis
4. Enzyme Inhibition: Inhibits dihydrofolate reductase
5. Biological Activity: Potential antifolate properties
6. Medical Applications: Potential anti-tumor and anti-inflammatory properties
7. Versatility: Wide range of potential applications in medicine and pharmaceutical research

Derivative of

Tyrosine

Usage

Intermediate in pharmaceutical and agrochemical synthesis

Enzyme Inhibition

Inhibits dihydrofolate reductase

Biological Activity

Potential antifolate properties

Medical Applications

Potential anti-tumor and anti-inflammatory properties

Upstream product

• 20099-90-5 4-(2-bromoacetyl)benzoic acid 
• 17356-08-0 thiourea 

Downstream Products

• 1092949-83-1 4-{2-[4-(1,1-dioxothiomorpholin-4-ylmethyl)benzoylamino]thiazol-4-yl}-N-(4-morpholin-4-ylphenyl)benzamide 
• 1092949-85-3 4-(2-aminothiazol-4-yl)-N-(4-morpholin-4-ylphenyl)benzamide 
• 942278-46-8 4-(2-amino-thiazol-4-yl)-N-cyclopropyl-benzamide 

Relevant articles and documents

Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV-1 Nucleocapsid Protein

Small molecule inhibitors of the HIV-1 nucleocapsid protein (NC) are considered as promising agents in the treatment of HIV/AIDS. In an effort to exploit the privileged 2-amino-4-phenylthiazole moiety in NC inhibition, here we conceived, synthesized, and tested in vitro 18 NC inhibitors (NCIs) bearing a double functionalization. In these NCIs, one part of the molecule is deputed to interact noncovalently with the NC hydrophobic pocket, while the second portion is designed to interact with the N-terminal domain of NC. This binding hypothesis was verified by molecular dynamics simulations, while the linkage between these two pharmacophores was found to enhance antiretroviral activity both on the wild-type virus and on HIV-1 strains with resistance to currently licensed drugs. The two most interesting compounds 6 and 13 showed no cytotoxicity, thus becoming valuable leads for further investigations.

AMIDO ANTI-VIRAL COMPOUNDS

Disclosed are compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof of having Formula (I), their preparation, use, and compositions thereof for treating an infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R3, X, V, W, T, Z, R, Y1, and p are as defined herein.

ANTI-VIRAL COMPOUNDS

Disclosed are compounds, stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof of having Formula (I), their preparation, use, and compositions thereof for treating an infection mediated at least in part by a virus in the Flavivi

ANTI-VIRAL INHIBITORS AND METHODS OF USE

Disclosed are compounds and compositions of Formula (I), pharmaceutically acceptable salts and solvates thereof, and their uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses.

N-(5-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS

Disclosed are compounds having Formula (I) and the compositions and methods thereof for treating or preventing a viral infection mediated at least in part by a virus in the Flaviviridae family of viruses, wherein A, R2, m, R, V, W, T, Z, R