216983-38-9

Upstream product

• 777-44-6 3-(Trifluoromethyl)benzenesulfonyl chloride 
• 41979-39-9 4-piperidone hydrochloride 

Downstream Products

• 216983-41-4 3-Bromo-1-(3-trifluoromethyl-benzenesulfonyl)-piperidin-4-one 
• 1092464-36-2 2-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-ylideneaminooxy)acetic acid 
• 1200797-13-2 1-(2-(4-fluorophenoxy)ethyl)-3-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yloxy)urea 
• 1200797-16-5 3-(4-fluorophenyl)-1-methyl-1-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yloxy)urea 
• 1200797-98-3 2-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yloxy)isoindoline-1,3-dione 
• 1200796-88-8 4-chloro-N-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yloxy)benzamide 
• 1200796-83-3 4-fluoro-N-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yloxy)benzamide 
• 1200797-10-9 1-propyl-3-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yloxy)urea 
• 1200797-04-1 1-ethyl-3-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yloxy)urea 
• 1200797-99-4 O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine 
• 1200798-06-6 N-methyl-O-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-yl)hydroxylamine 
• 1092464-03-3 1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-one O-4-fluorophenylcarbamoyl oxime 
• 1092464-10-2 1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-one O-(4-fluorophenyl)(methyl)carbamoyl oxime 
• 1092463-04-1 N-(thiazol-2-yl)-2-(1-(3-(trifluoromethyl)phenylsulfonyl)piperidin-4-ylideneaminooxy)acetamide 

Relevant academic research and scientific papers

Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents

Polymer-supported reagents and other solid sequestering agents may be used to generate a library of piperidino-thiomorpholine derivatives without any chromatographic purification steps.

SOLUBLE EPOXIDE HYDROLASE INHIBITORS

Disclosed are alpha keto amide and alpha hydroxy amide compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, pulmonary, and diabetic-related diseases.