216988-53-3

Basic information

• Product Name: methyl 5-(2-furyl)-2-(4-tolylsulfonylamino)pent-4-ynoate
• Synonyms: methyl 5-(2-furyl)-2-(4-tolylsulfonylamino)pent-4-ynoate
• CAS NO: 216988-53-3
• Molecular Weight: 347.392
• Mol File: 216988-53-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 5-(2-furyl)-2-(4-tolylsulfonylamino)pent-4-ynoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-(2-furyl)-2-(4-tolylsulfonylamino)pent-4-ynoate(216988-53-3)
• EPA Substance Registry System: methyl 5-(2-furyl)-2-(4-tolylsulfonylamino)pent-4-ynoate(216988-53-3)

Safety Data

• Hazardous Substances Data: 216988-53-3(Hazardous Substances Data)

Upstream product

• 167904-79-2 methyl (R,S)-2-(N-diphenylmethylidene)aminopent-4-ynoate 
• 70837-20-6 propargyclycine methyl ester hydrochloride 
• 54829-48-0 2-iodofuran 
• 191215-76-6 methyl 2-[(4-toluenesulfonyl)amino]-4-pentynoate 

Downstream Products

• 216988-57-7 methyl 5-(2-furyl)-4-iodo-1-(4-tolylsulfonyl)-2,3-dihydropyrrole-2-carboxylate 

Relevant articles and documents

An approach to 2,3-dihydropyrroles and β-iodopyrroles based on 5-endo-dig cyclisations

A representative series of homopropargylic sulfonamides 19 and 22b have been found to undergo smooth 5-endo-dig cyclisation upon exposure to excess iodine in acetonitrile containing potassium carbonate. The resulting 4-iodo-2,3-dihydropyrroles 23 readily react with two equivalents of DBU in DMF at 20°C to give the corresponding β-iodopyrroles 24 and 26 in excellent yields by the elimination of toluene-p-sulfinic acid. Use of less than two equivalents of base results in some loss of iodine. The iodo-2,3-dihydropyrroles 23 can be used in palladium-catalysed coupling reactions as shown by the efficient formation of the Sonogashira product 29 under mild conditions.