21703-55-9Relevant articles and documents
A Colorimetric Fluorescent Probe for SO2 Derivatives-Bisulfite and Sulfite at Nanomolar Level
Zhang, Jian,Peng, Aidong,Lv, Yanlin,Zhang, Yuanlin,Wang, Xuefei,Zhang, Guangjin,Tian, Zhiyuan
, p. 1767 - 1775 (2017)
A colorimetric fluorescent probe with fluorescence emission feature sensitive to SO2 derivatives, i.e. bisulfite (HSO3 ?) and sulfite (SO3 2?), was developed based on the HSO3 ?/SO3 2?-mediated nucleophilic addition reaction of the probe that. This probe exhibited SO3 2? sensing ability with detection limit down to 46?nM and desired selectivity over other reference anions and redox species. The preliminary fluorescence bioimaging experiments have validated the practicability of the as-prepared probe for SO2 derivatives sensing in living cells.
A benzothiazole-based fluorescent probe for hypochlorous acid detection and imaging in living cells
Nguyen, Khac Hong,Hao, Yuanqiang,Zeng, Ke,Fan, Shengnan,Li, Fen,Yuan, Suke,Ding, Xuejing,Xu, Maotian,Liu, You-Nian
, p. 189 - 193 (2018)
A benzothiazole-based turn-on fluorescent probe with a large Stokes shift (190 nm) has been developed for hypochlorous acid detection. The probe displays prompt fluorescence response for HClO with excellent selectivity over other reactive oxygen species as well as a low detection limit of 0.08 μM. The sensing mechanism involves the HClO-induced specific oxidation of oxime moiety of the probe to nitrile oxide, which was confirmed by HPLC-MS technique. Furthermore, imaging studies demonstrated that the probe is cell permeable and can be applied to detect HClO in living cells.
An ESIPT-based fluorescent probe with fast-response for detection of hydrogen sulfide in mitochondria
Bi, Minjie,Du, Yuting,Li, Zhiying,Liu, Juan,Wang, Hongliang,Wen, Wei,Zhang, Ting
supporting information, (2021/09/20)
Excited-state intramolecular proton transfer (ESIPT) has recently received considerable attention due to its dual fluorescent changes and large Stokes shift. Hydrogen sulfide (H2S) is a gas signal molecule that plays important roles in modulating the functions of different systems. Herein, by modifying 2-(2?-hydroxyphenyl) benzothiazole (HBT) scaffold, a novel near-infrared mitochondria-targeted fluorescent probe HBTP-H2S has been rationally designed based on excited-state intramolecular proton transfer (ESIPT) effect. The nucleophilic addition reaction of the H2S with probe HBTP-H2S caused the break of the conjugated skeleton, resulting the shifting of maximum emission peak from 658 nm to 470 nm. HBTP-H2S showed fast-response response time, good selectivity and a large Stokes shift (188 nm) toward H2S. Most importantly, inspired by the inherent advantages of the probe, HBTP-H2S was successfully employed to monitor mitochondrial H2S in HepG2 cells.
HBT-based methyl derivative fluorescent probe and preparation and application thereof
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Paragraph 0032-0035, (2021/11/10)
The invention provides a fluorescent probe 5-HBT as well as preparation and application of the fluorescent probe 5-HBT to fluorescence detection through research on introduction of methyl groups at different positions on a benzene ring of an HBT molecule, so residual sodium hypochlorite in a water body can be rapidly and visually detected on site. Studies prove that the position of a methyl group on a benzene ring can generate huge influence on some fluorescent molecules, mainly including fluorescence intensity and fluorescence stability, and most obviously, 5-HBT fluorescence is greatly weakened; and the obtained 5-HBT probe can emit fluorescence in a solid state, has great advantages when used for manufacturing a paper fluorescence sensor, is obvious in fluorescence effect, and can rapidly and visually detect a sodium hypochlorite solution on site.
A highly selective AIEgen fluorescent probe for visualizing Cys in living cells andC. elegans
Chen, Xin-Yue,Jiao, Qing-Cai,Wang, Bao-Zhong,Wang, Zhong-Chang,Xu, Zhu-Min,Ye, Ya-Xi,Yu, Ya-Wen,Zhu, Hai-Liang
, p. 19073 - 19081 (2021/10/26)
As essential biological thiols in organisms, Cys, Hcy, and GSH are closely related to each other, and they can be involved in various pathological processes if expression levels are abnormal. It is a challenge to develop effective fluorescence-based tools to selectively distinguish Cys from Hcy and GSH because of their common functional groups. For most existing Cys fluorescent probes, their application is greatly restricted by the influence of aggregation-caused quenching (ACQ). In this work, a novel fluorescent probe,PE-YW, for Cys was designed rationallyviaregulating its AIE-based effects. The probePE-YWtook advantage of a specific conjugate addition cyclization reaction between Cys and an acrylate moiety, inducing the aggregation ofPE-OHand showing large turn-on fluorescence (about 7-fold). The probe could detect Cys over other amino acids with high selectivity and a low detection limit (LOD = 1.72 nM). In addition,PE-YWexhibited excellent performance, such as a high fluorescence quantum yield (δ= 0.8) and a fast response toward Cys (a suitable and potential fluorescence-based tool for detecting Cys in living systems.
