217076-48-7Relevant academic research and scientific papers
An asymmetric synthetic route to (+)-lactacystin
Kang, Sung Ho,Jun, Hyuk-Sang,Youn, Joo-Hack
, p. 1045 - 1046 (2007/10/03)
Trihydroxy pyrrolidinone 16, a key intermediate to (+)-lactacystin 1, has been stereoselectively synthesized via the highly diastereoselective crotylboration of aldehyde 5 and intramolecular mercurioamidation of allylic trichloroacetimidate 12 to introduce the three requisite contiguous chiral centers of methyl, hydroxy and amino substituents.
