217081-29-3Relevant academic research and scientific papers
COUMARIN DERIVATIVES, METHODS OF PREPARATION AND APPLICATION AND APPLICATION AS MEDICINES
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, (2008/06/13)
The invention concerns compounds of general formula (I) in which: X, X' and X" independently of each other represent O or S; Y represents O, S, NH or NHS; R 3 represents in particular a cycloalkyl group; R 5, R 6, R 7 and R 8 mutually identical or different, represent in particular hydrogen; a halogen atom. Said compounds can be used as active substances of medicines as inhibitors of protease. "
Coumarinic derivatives as mechanism-based inhibitors of α-chymotrypsin and human leukocyte elastase
Pochet, Lionel,Doucet, Caroline,Dive, Georges,Wouters, Johan,Masereel, Bernard,Reboud-Ravaux, Michele,Pirotte, Bernard
, p. 1489 - 1501 (2007/10/03)
Novel coumarinic derivatives were synthesized and tested for their inhibitory potency toward α-CT and HLE. Cycloalkyl esters and amides were found to be essentially inactive on both enzymes. On the opposite, aromatic esters strongly inactivated α-CT where
