21714-23-8

Upstream product

• 6590-91-6 1-(2,6-dichlorophenyl)thiourea 
• 506-68-3 bromocyane 
• 608-31-1 2,6-Dichloroaniline 

Downstream Products

• 39075-78-0 2.6-Dichlorophenylguanidin 
• 731858-90-5 N-(2,6-dichlorophenyl)-N'-(2-methyl-[1,3]dioxolan-2-ylmethyl)-guanidine trifluoroacetate 
• 731858-93-8 (2,6-dichlorophenyl)-methyl-cyanamide 
• 731858-92-7 N-(2,6-dichlorophenyl)-N'-(1,4-dioxa-spiro[4,5]dec-6-yl)-guanidine 

Relevant academic research and scientific papers

COMPOSITIONS AND METHODS FOR THE TREATMENT OF MUCOSITIS

The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of mucositis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of mucus diseases related to painful inflammation and ulceration of the digestive tract lining and in the mouth.

Novel 2,6-di-substituted phenyl-aminoquanidine containing compositions and methods of using same and pharmaceutical compositions containing the same and therapeutic method

The invention relates to compounds of the general formula: STR1 in which one double bond is present between the carbon atom of the quanidine moiety and one of the adjacent nitrogen atoms and R0 stands for hydrogen, halogen, hydroxy, alkoxy or alkyl (1 to 6 C), R1, r2 for halogen, hydroxy, alkyl (1 to 4 C) or alkoxy (1 to 4 C), R3, r3 ', r3 " for hydrogen or alkyl (1 to 4 C), on the understanding that one of the substituents R3, R3 ' or R3 " is absent because of the presence of the double bond, R4 for hydrogen, alkyl (1-4 C), hydroxy, alkoxy (1-4 C) or amino optionally substituted with one or two alkyl (1 to 4 C) groups, R5, r6 for hydrogen, alkyl (1-6 C), acyl or R5 + R6 together represent an alkylidene, cyclic alkylidene or aralkylidene group, as well as the acid addition salts thereof, Provided that, if R4 stands for methyl and R0, R3, R3 ", R5 and R6 for hydrogen, R1 and R2 may not represent methyl simultaneously, having a strong and long-acting anti-hypertensive activity.

Novel 2,6-disubstituted phenyl-aminoguanidine compounds

The invention relates to compounds of the general formula: EQU1 in which one double bond is present between the carbon atom of the guanidine moiety and one of the adjacent nitrogen atoms and R0 stands for hydrogen, halogen, hydroxy, alkoxy or alkyl (1 to 6 C), R1, r2 for halogen, hydroxy, alkyl (1 to 4 C) or alkoxy (1 to 4 C), R3, r3 ', r3 " for hydrogen or alkyl (1 to 4 C) on the understanding that one of the substituents R3, R3 ' or R3 " is absent because of the presence of the double bond, R4 for hydrogen, alkyl (1-4 C), hydroxy, alkoxy (1-4 C) or amino optionally substituted with one or two alkyl (1 to 4 C) groups, R5, r6 for hydrogen, alkyl (1-6 C), acyl or R5 + R6 together represent an alkylidene, cyclic alklidene or aralkylidene group, As well as the acid addition salts thereof, provided that, if R4 stands for methyl and R0, R3, R3 ", R5 and R6 for hydrogen, R1 and R2 may not represent methyl simultaneously, having a strong and long-acting anti-hypertensive activity.