217170-69-9

Upstream product

• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 5455-98-1 2-oxiranylmethylisoindole-1,3-dione 
• 136918-14-4 phthalimide 

Downstream Products

• 217170-70-2 α-(aminomethyl)-4-[2-(1-methoxy)phenyl]-1-piperazineethanol 
• 217170-68-8 3-{2-Hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-1H-quinazoline-2,4-dione 
• 217170-71-3 2-Amino-N-{2-hydroxy-3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propyl}-benzamide 

Relevant academic research and scientific papers

Design, Synthesis and Antimalarial Activity of Some New minoalcoholpyrrolo[ 1,2-A]quinoxaline Derivatives

Following our search for antimalarial compounds, novel series of piperazinylalcohol pyrrolo 1,2-A]quinoxaline derivatives 1-2 were synthesized from 2-nitroaniline or 2-Amino-3 nitrophenol and tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodiu falciparum strains. Biological results showed good antimalarial activity with IC50 ranging fro 0.3 to 21.1 M. In attempting to investigate the large broad-spectrum antiprotozoal activities of thes pyrrolo[1,2-A]quinoxaline derivatives, their properties toward the promastigote form of Leishmani donovani were also investigated and revealed their selective antiplasmodial profile. In parallel, the i vitro cytotoxicity of these molecules was assessed on the human HepG2 cell line. Structure-Activit relationships of these new synthetic compounds are here discussed.

Studies on quinazolines IX:1 Fluorination versus 1,2-migration in the reaction of 1,3-bifunctionalized amino-2-propanol with DAST

Treatment of 1-phthaloylamino-3-[4-(2-methoxyphenyl)piperazin-1-yl]- propanol (7) with DAST induced 1,2-migration via a proposed spiro-aziridinium intermediate to give N-[2-fluoro-3-[4-(2-methoxyphenyl)piperazin-1- yl]propyl]-phthalimide (11a) in 13% yield and N-12-fluoromethyl-2-[4-(2- methoxyphenyl)-piperazin-1-yl]ethyl]phthalimide (11b) in 73% yield.