217170-75-7Relevant academic research and scientific papers
Studies on quinazolines IX:1 Fluorination versus 1,2-migration in the reaction of 1,3-bifunctionalized amino-2-propanol with DAST
Chern, Ji-Wang,Chang, Jun-Yi,Usifoh, Cyril O.,Gutsait, Alexander
, p. 8483 - 8486 (1998)
Treatment of 1-phthaloylamino-3-[4-(2-methoxyphenyl)piperazin-1-yl]- propanol (7) with DAST induced 1,2-migration via a proposed spiro-aziridinium intermediate to give N-[2-fluoro-3-[4-(2-methoxyphenyl)piperazin-1- yl]propyl]-phthalimide (11a) in 13% yield and N-12-fluoromethyl-2-[4-(2- methoxyphenyl)-piperazin-1-yl]ethyl]phthalimide (11b) in 73% yield.
