217172-40-2Relevant academic research and scientific papers
Facile synthesis of L-Dopa tert-butyl ester by catalytic enantioselective phase-transfer alkylation
Ooi,Kameda,Tannai,Maruoka
, p. 8339 - 8342 (2000)
Facile asymmetric synthesis of L-Dopa and related amino acid esters has been achieved by phase-transfer catalysis of the rationally designed C2-symmetric chiral quaternary ammonium salts 1. The 'scale-up' experiment performed with 5.00 g of tert-butyl glycinate-benzophenone Schiff base (2) represents the practical aspect of our approach. (C) 2000 Elsevier Science Ltd.
Antifungal amino acid derivative
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Paragraph 0145-0147, (2018/06/12)
PROBLEM TO BE SOLVED: To provide a new antifungal compound and an amino acid derivative with antifungal properties.SOLUTION: This invention relates to a compound represented by NHR-CHR-C(O)-R(I) or salt thereof, and an antifungal agent including the compound or salt thereof.
Design of N-spiro C2-symmetric chiral quaternary ammonium bromides as novel chiral phase-transfer catalysts: Synthesis and application to practical asymmetric synthesis of α-amino acids
Ooi, Takashi,Kameda, Minoru,Maruoka, Keiji
, p. 5139 - 5151 (2007/10/03)
A series of C2-symmetric chiral quaternary ammonium bromides 10 and 11 have been designed as a new, purely synthetic chiral phase-transfer catalyst, and readily prepared from commercially available optically pure 1,1′-bi-2-naphthol as a basic c
Peptidyl calcium channel blockers
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, (2008/06/13)
The present invention provides compounds that block calcium channels having the Formula I shown below. The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.
Design of new, chiral phase-transfer catalysts for practical, catalytic asymmetric synthesis
Maruoka, Keiji
, p. 95 - 99 (2007/10/03)
Structurally rigid, chiral spiro ammonium salts of type 1 derived from commercially available (S)-binaphthol have been designed as a new C2-symmetric chiral phase-transfer catalyst and successfully applied to the highly efficient, catalytic enantioselective alkylation of tert-butyl glycinate Schiff base under mild phase-transfer conditions to furnish a-alkyl-oc-amino acids and α,α-dialkyl-α-amino acids with excellent enantioselectivity. These ammonium salts have been also utilized for the in situ generation of chiral quaternary ammonium fluorides.
Substituted peptidylamine calcium channel blockers
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, (2008/06/13)
PCT No. PCT/US98/10838 Sec. 371 Date Jan. 19, 1999 Sec. 102(e) Date Jan. 19, 1999 PCT Filed May 28, 1998 PCT Pub. No. WO98/54123 PCT Pub. Date Dec. 3, 1998The present invention provides compounds that block calcium channels having the Formula I shown belo
