217191-47-4Relevant academic research and scientific papers
N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships, and in Vitro Pharmacology
Pallesen, Jakob,M?llerud, Stine,Frydenvang, Karla,Pickering, Darryl S.,Bornholdt, Jan,Nielsen, Birgitte,Pasini, Diletta,Han, Liwei,Marconi, Laura,Kastrup, Jette Sandholm,Johansen, Tommy N.
, p. 1841 - 1853 (2019)
Among the ionotropic glutamate receptors, the physiological role of kainate receptors is less well understood. Although ligands with selectivity toward the kainate receptor subtype GluK1 are available, tool compounds with selectivity at the remaining kain
A versatile method for the synthesis of benzimidazoles from o-nitroanilines and aldehydes in one step via a reductive cyclization
Yang, Donglai,Fokas, Demosthenes,Li, Jingzhou,Yu, Libing,Baldino, Carmen M.
, p. 47 - 56 (2007/10/03)
A highly efficient and versatile method for the synthesis of benzimidazoles was achieved in one step via the Na2S2O4 reduction of o-nitroanilines in the presence of aldehydes. Heating a solution of o-nitroaniline (Ic) and an aldehyde in EtOH or another appropriate solvent, in the presence of aqueous or solid Na2S2O4, provided facile access to a series of 2-substituted N-H benzimidazoles 5a-m containing a wide range of functional groups not always compatible with the existing synthetic methods. This methodology has also been applied to the regioselective synthesis of N-alkyl and N-aryl benzimidazoles 6a-f via the cyclization of the corresponding N-substituted nitroanilines 13a-e, respectively. In addition, the method was applied successfully to the synthesis of other imidazole containing heterocyclic ring systems such as 1H-imidazo[4,5-b]pyridines 14a,b and 1H-imidazo[4,5-f]quinoline 15.
