217197-08-5Relevant academic research and scientific papers
Trifluoromethyl group as a pharmacophore: Effect of replacing a CF 3 group on binding and agonist activity of a glucocorticoid receptor ligand
Betageri, Raj,Zhang, Yan,Zindell, Renee M.,Kuzmich, Daniel,Kirrane, Thomas M.,Bentzien, Joerg,Cardozo, Mario,Capolino, Alison J.,Fadra, Tazmeen N.,Nelson, Richard M.,Paw, Zofia,Shih, Daw-Tsun,Shih, Cheng-Kon,Zuvela-Jelaska, Ljiljana,Nabozny, Gerald,Thomson, David S.
, p. 4761 - 4769 (2007/10/03)
Compound 1, a potent glucocorticoid receptor ligand, contains a quaternary carbon bearing trifluoromethyl and hydroxyl groups. This paper describes the effect of replacing the trifluoromethyl group on binding and agonist activity of the GR ligand 1. The r
