217199-46-7Relevant academic research and scientific papers
Synthesis and enzymic evaluation of 4-mercapto-6-oxo-1,4- azaphosphinane-2-carboxylic acid 4-oxide as an inhibitor of mammalian dihydroorotase
Manthey, Michael K.,Huang, Danny T. C.,Bubb, William A.,Christopherson, Richard I.
, p. 4550 - 4555 (1998)
The design, synthesis, and enzymic evaluation of cis- and trans-4- mercapto-6-oxo-1,4-azaphosphinane-2-carboxylic acid 4-oxide 5 against mammalian dihydroorotase is presented. The design strategy for 5 was based on the strong affinity of phosphinothioic a
