217298-89-0

Upstream product

• 217298-94-7 (2R,3R,4R,5R,6S)-3,4,5-Tris-benzyloxy-2-benzyloxymethyl-6-methyl-piperidine 

Downstream Products

• 217298-92-5 n-propyl 2-acetamido-2,3-dideoxy-4-O-(β-D-galactopyranosyl)-6-O-benzyl-3-amino-3-N-{2-[N-(1,3,4,5-tetra-O-benzyl-β-L-homofuconojirimycinyl)]ethyl}-β-D-glucopyranoside 
• 217298-90-3 n-propyl 2-acetamido-2,3-dideoxy-6-O-benzyl-3-amino-3-N-{2-[N-(1,3,4,5-tetra-O-benzyl-β-L-homofuconojirimycinyl)]ethyl}-β-D-glucopyranoside 

Relevant academic research and scientific papers

Chemoenzymatic synthesis of iminocyclitol derivatives: A useful library strategy for the development of selective fucosyltransfer enzymes inhibitors

A chemoenzymatic strategy has been developed for the synthesis of libraries of iminocyclitol derivatives for the discovery of new and selective fucosidase inhibitors.

Synthesis of a new class of N-linked lewis and LacNac analogues as potential inhibitors of human fucosyltransferases: A general method for the incorporation of an iminocyclitol as a transition-state mimetic of the donor sugar to the acceptor

A short and effective synthesis of N-linked di- and trisaccharides is described. In a high-yielding reaction sequence, the glucosamine derivative 1 was transformed to the 3-azido-2,3-dideoxy sugar 2e under excellent stereocontrol. The LacNAc analogue 4d was synthesized as a single isomer in three steps starting from 2e. In a one-pot procedure, iminocyclitol 5 was transformed into aldehyde 6 and successfully used for reductive amination with 4c and 2f to give trisaccharide 8a and disaccharide 7a, respectively. This procedure represents a general strategy for the incorporation of an iminocyclitol as a transition-state mimic of the donor sugar moiety to the acceptor.