21732-93-4

Basic information

• Product Name: 1,4-Dichloro-2,3-benzenediamine
• Synonyms: 1,4-Dichloro-2,3-benzenediamine;3,6-dichlorobenzene-1,2-diaMine;3,6-Dichloro-1,2-benzenediamine
• CAS NO: 21732-93-4
• Molecular Formula: C₆H₆Cl₂N₂
• Molecular Weight: 177.03
• Mol File: 21732-93-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 98 °C(Solv: ethanol, 50% (64-17-5))
• Boiling Point: 291.3±35.0 °C(Predicted)
• Appearance: /
• Density: 1.501±0.06 g/cm3(Predicted)
• PKA: 1.46±0.10(Predicted)
• CAS DataBase Reference: 1,4-Dichloro-2,3-benzenediamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dichloro-2,3-benzenediamine(21732-93-4)
• EPA Substance Registry System: 1,4-Dichloro-2,3-benzenediamine(21732-93-4)

Safety Data

• Hazardous Substances Data: 21732-93-4(Hazardous Substances Data)

Usage

General Description

1,4-Dichloro-2,3-benzenediamine, also known as p-Phenylenediamine or 1,4-Diaminobenzene, is a chemical compound commonly used in the production of hair dyes, textile dyes, and rubber processing. It is a white, crystalline solid that is soluble in water and organic solvents. 1,4-Dichloro-2,3-benzenediamine is also used in the manufacturing of corrosion inhibitors, antioxidants, and pharmaceuticals. However, prolonged exposure to 1,4-Dichloro-2,3-benzenediamine can lead to skin irritation, allergic reactions, and respiratory problems, making it important to handle and use with caution.

Upstream product

• 2207-34-3 4,7-dichlorobenzo[c][1,2,5]thiadiazole 
• 273-13-2 benzo[1,2,5]thiadiazole 
• 89-61-2 2,5-dichloronitrobenzene 
• 65036-57-9 1,4-dichloro-2,3-dinitrobenzene 
• 15944-74-8 3,6-dichloro-2-nitro-aniline 

Downstream Products

• 1196131-60-8 4,7-dichloro-2-(4-fluorophenyl)-1H-benzimidazole 
• 102466-68-2 3-(4,7-dichloro-benzotriazol-2-yl)-1,3-diphenyl-propan-1-one 
• 1225652-20-9 5,8-dichloro-2-methyl-3-[3'-(methylsulfonyl)biphenyl-4-yl]quinoxaline 
• 94544-96-4 5,8-dichloro-2,3-diphenyl-quinoxaline 

Relevant articles and documents

Programmed Sequential Additions to Halogenated Mucononitriles

Dihalomucononitriles were synthesized and their reactivity evaluated to assess their ability to function as linchpin reagents. Bis(2-chloroacrylonitrile) and bis(2-bromoacrylonitrile) were synthesized from 2,1,3-benzothiadiazole and undergo conjugate addition/elimination reactions with both nitrogen (40-95% yield) and carbon nucleophiles (72-93% yield). Secondary amines undergo monosubstitutions, while carbon nucleophiles are added twice. The sequence of addition of the nucleophiles could be controlled to give mixed addition products. The multicomponent coupling products could then be converted to natural product like motifs using intramolecular cyclization reactions.

Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles

(Chemical Equation Presented) A series of 47 novel N1-alkylated- 2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogues were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that compounds 79 and 80, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 μg/mL. Indole analogues 108-110 have no inhibitory activity.