21735-78-4Relevant articles and documents
Concise synthesis of (+)-serinolamide A
Gao, Ya-Ru,Guo, Shi-Huan,Zhang, Zhuan-Xiang,Mao, Shuai,Zhang, Yan-Lei,Wang, Yong-Qiang
, p. 6511 - 6513 (2013/11/19)
Serinolamide A, isolated from a species of marine cyanobacteria, exhibits a moderate agonist effect and selectivity for the CB1 cannabinoid receptor, which is unusual for marine natural products. Herein, we reported a highly efficient enantiospecific first total synthesis of (+)-serinolamide A from l-serine in nine steps with 30% overall yield. The synthesis method provides a facile, practicable, and economical approach for the preparation of other similar endocanabinoid lipids.