217435-74-0Relevant academic research and scientific papers
Synthesis of imidazo[1,2-a]pyridines as antiviral agents
Gueiffier,Mavel,Lhassani,Elhakmaoui,Snoeck,Andrei,Chavignon,Teulade,Witvrouw,Balzarini,De Clercq,Chapat
, p. 5108 - 5112 (1998)
The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic
KIO4-mediated Selective Hydroxymethylation/Methylenation of Imidazo-Heteroarenes: A Greener Approach
Braga, Antonio Luiz,Franco, Marcelo Straesser,Rafique, Jamal,Saba, Sumbal
supporting information, p. 18454 - 18460 (2021/07/21)
Herein, we report a KIO4-mediated, sustainable and chemoselective approach for the one-pot C(sp2)?H bond hydroxymethylation or methylenation of imidazo-heteroarenes with formaldehyde, generated in situ via the oxidative cleavage of ethylene glycol or glycerol (renewable reagents) through the Malaprade reaction. In the presence of ethylene glycol, a series of 3-hydroxymethyl-imidazo-heteroarenes was obtained in good to excellent yields. These compounds are important intermediates to access pharmaceutical drugs, e.g., Zolpidem. Furthermore, by using glycerol, bis(imidazo[1,2-a]pyridin-3-yl)methane derivatives were selectively obtained in good to excellent yields.
